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. 1986 Dec;89(4):831–835. doi: 10.1111/j.1476-5381.1986.tb11188.x

Muscarinic and nicotinic mechanisms in the responses of the adrenal medulla of the dog and cat to reflex stimuli and to cholinomimetic drugs.

J A Critchley, P Ellis, C G Henderson, A Ungar, C P West
PMCID: PMC1917227  PMID: 3814911

Abstract

In isolated perfused adrenal glands of the cat, muscarinic and nicotinic agonists selectively released adrenaline and noradrenaline respectively. In isolated perfused adrenal glands of the dog, the output of adrenaline and noradrenaline remained in a fixed ratio at rest and when stimulated by muscarinic or by nicotinic agonists. In the anaesthetized dog, a combination of muscarinic and nicotinic antagonists was needed to block reflex responses of the adrenal medulla. A nicotinic antagonist was more effective in blocking the baroreceptor reflex response than the chemoreceptor reflex response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barlow R. B., Franks F. Specificity of some ganglion stimulants. Br J Pharmacol. 1971 May;42(1):137–142. doi: 10.1111/j.1476-5381.1971.tb07093.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Critchley J. A., Ellis P., Henderson C. G., Ungar A. The role of the pituitary-adrenocortical axis in reflex responses of the adrenal medulla of the dog. J Physiol. 1982 Feb;323:533–541. doi: 10.1113/jphysiol.1982.sp014090. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Critchley J. A., Ellis P., Ungar A. The reflex release of adrenaline and noradrenaline from the adrenal glands of cats and dogs. J Physiol. 1980 Jan;298:71–78. doi: 10.1113/jphysiol.1980.sp013067. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Critchley J. A., Tibenham J. I., ungar A., Waite J., West C. P. Proceedings: The effects of nicotinic and muscarinic agonist drugs on the release of catecholamines from the isolated perfused adrenal glands of the dog. Br J Pharmacol. 1975 Jun;54(2):259P–260P. [PMC free article] [PubMed] [Google Scholar]
  5. Critchley J. A., Ungar A. A chemical method of lowering the P0-2 of blood in experimental studies of arterial chemoreceptor reflexes. J Physiol. 1975 Jan;244(1):12P–13P. [PubMed] [Google Scholar]
  6. Douglas W. W., Poisner A. M. Preferential release of adrenaline from the adrenal medulla by muscarine and pilocarpine. Nature. 1965 Dec 11;208(5015):1102–1103. doi: 10.1038/2081102a0. [DOI] [PubMed] [Google Scholar]
  7. Feldberg W., Minz B., Tsudzimura H. The mechanism of the nervous discharge of adrenaline. J Physiol. 1934 Jun 9;81(3):286–304. doi: 10.1113/jphysiol.1934.sp003136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Henderson C. G., Ungar A. Antagonist affinity constants for adrenomedullary muscarinic receptors [proceedings]. Br J Pharmacol. 1977 Mar;59(3):499P–500P. [PMC free article] [PubMed] [Google Scholar]
  9. Henderson C. G., Ungar A. Effect of cholinergic antagonists on sympathetic ganglionic transmission of vasomotor reflexes from the carotid baroreceptors and chemoreceptors of the dog. J Physiol. 1978 Apr;277:379–385. doi: 10.1113/jphysiol.1978.sp012278. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ungar A., Phillips J. H. Regulation of the adrenal medulla. Physiol Rev. 1983 Jul;63(3):787–843. doi: 10.1152/physrev.1983.63.3.787. [DOI] [PubMed] [Google Scholar]

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