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. 1986 Dec;89(4):635–640. doi: 10.1111/j.1476-5381.1986.tb11167.x

Feline endotoxin shock: effects on tissue histamine and histidine decarboxylase activity.

J R Parratt, S Saleh, N G Waton
PMCID: PMC1917246  PMID: 2434172

Abstract

Tissue histamine levels as well as specific and non-specific histidine decarboxylase were examined before and at various times (5 and 10 min) after the intravenous injection of a lethal dose (2 mg kg-1) of E. coli endotoxin in anaesthetized cats. Histamine levels were increased 5 min after endotoxin, especially in the skin, liver, lung and stomach. There was evidence, in most of the cats, for a rapid and substantial activation of specific histidine decarboxylase especially in the lungs, liver, heart and gastrointestinal tract 5-10 min after endotoxin administration. It is suggested that endotoxin induces the local formation of histamine and that this formation and local release may contribute to the pathophysiology of endotoxin shock in this species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON F. L., KUIDA H., HECHT H. H. Influence of promethazine on circulatory response to endotoxin in dogs. Am J Physiol. 1963 Jun;204:983–986. doi: 10.1152/ajplegacy.1963.204.6.983. [DOI] [PubMed] [Google Scholar]
  2. Aures D., Davidson W. D., Håkanson R. Histidine decarboxylase in gastric mucosa of various mammals. Eur J Pharmacol. 1969 Oct;8(1):100–107. doi: 10.1016/0014-2999(69)90134-4. [DOI] [PubMed] [Google Scholar]
  3. Brackett D. J., Schaefer C. F., Wilson M. F. The effects of H1 and H2 histamine receptor antagonists on the development of endotoxemia in the conscious, unrestrained rat. Circ Shock. 1985;16(2):141–153. [PubMed] [Google Scholar]
  4. Emau P., Giri S. N., Bruss M. L. Role of prostaglandins, histamine, and serotonin in the pathophysiology induced by Pasteurella hemolytica endotoxin in sheep. Circ Shock. 1984;12(1):47–59. [PubMed] [Google Scholar]
  5. HINSHAW L. B., EMERSON T. E., Jr, IAMPIETRO P. F., BRAKE C. M. A comparative study of the hemodynamic actions of histamine and endotoxin. Am J Physiol. 1962 Oct;203:600–606. doi: 10.1152/ajplegacy.1962.203.4.600. [DOI] [PubMed] [Google Scholar]
  6. HINSHAW L. B., JORDAN M. M., VICK J. A. Mechanism of histamine release in endotoxin shock. Am J Physiol. 1961 May;200:987–989. doi: 10.1152/ajplegacy.1961.200.5.987. [DOI] [PubMed] [Google Scholar]
  7. Hughes B., Parratt J. R. The effects of the protease inhibitor, aprotinin, on the course of shock induced by endotoxin in cats. Br J Pharmacol. 1985 Oct;86(2):399–403. doi: 10.1111/j.1476-5381.1985.tb08909.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. ICK J. A. BIOASSAY OF THE PROMINENT HUMORAL AGENTS INVOLVED IN ENDOTOXIN SHOCK. Am J Physiol. 1965 Jul;209:75–78. doi: 10.1152/ajplegacy.1965.209.1.75. [DOI] [PubMed] [Google Scholar]
  9. KAHLSON G., ROSENGREN E., SVAHN D., THUNBERG R. MOBILIZATION AND FORMATION OF HISTAMINE IN THE GASTRIC MUCOSA AS RELATED TO ACID SECRETION. J Physiol. 1964 Nov;174:400–416. doi: 10.1113/jphysiol.1964.sp007494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. KAMESWARAN L., WEST G. B. The formation of histamine in mammals. J Physiol. 1962 Mar;160:564–571. doi: 10.1113/jphysiol.1962.sp006866. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Krause S. M., Hess M. L. Diphenhydramine protection of the failing myocardium during gram-negative endotoxemia. Circ Shock. 1979;6(1):75–87. [PubMed] [Google Scholar]
  12. Nagy S., Nagy A., Adamicza A., Szabó I., Tárnoky K., Traub A. Histamine level changes in the plasma and tissues in hemorrhagic shock. Circ Shock. 1986;18(3):227–239. [PubMed] [Google Scholar]
  13. Parratt J. R. Myocardial and circulatory effects of E. coli endotoxin; modification of responses to catecholamines. Br J Pharmacol. 1973 Jan;47(1):12–25. doi: 10.1111/j.1476-5381.1973.tb08154.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Parratt J. R., Sturgess R. M. The possible roles of histamine, 5-hydroxytryptamine and prostaglandin F2alpha as mediators of the acute pulmonary effects of endotoxin. Br J Pharmacol. 1977 Jun;60(2):209–219. doi: 10.1111/j.1476-5381.1977.tb07743.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Reilly M. A., Schayer R. W. Further studies on the histidine-histamine relationship in vivo: effects of endotoxin and of histidine decarboxylase inhibitors. Br J Pharmacol. 1968 Nov;34(3):551–563. doi: 10.1111/j.1476-5381.1968.tb08484.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Reilly M. A., Schayer R. W. In vivo studies on histamine catabolism and its inhibition. Br J Pharmacol. 1970 May;38(3):478–489. doi: 10.1111/j.1476-5381.1970.tb10590.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. SCHAYER R. W. Relationship of induced histidine decarboxylase activity and histamine synthesis to shock from stress and from endotoxin. Am J Physiol. 1960 Jun;198:1187–1192. doi: 10.1152/ajplegacy.1960.198.6.1187. [DOI] [PubMed] [Google Scholar]
  18. SCHAYER R. W. Relationship of stress-induced histidine decarboxylase to circulatory homeostasis and shock. Science. 1960 Jan 22;131(3395):226–227. doi: 10.1126/science.131.3395.226. [DOI] [PubMed] [Google Scholar]
  19. SCHAYER R. W. The metabolism of histamine in various species. Br J Pharmacol Chemother. 1956 Dec;11(4):472–473. doi: 10.1111/j.1476-5381.1956.tb00020.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. SPINK W. W., DAVIS R. B., POTTER R., CHARTRAND S. THE INITIAL STAGE OF CANINE ENDOTOXIN SHOCK AS AN EXPRESSION OF ANAPHYLACTIC SHOCK: STUDIES ON COMPLEMENT TITERS AND PLASMA HISTAMINE CONCENTRATIONS. J Clin Invest. 1964 Apr;43:696–704. doi: 10.1172/JCI104954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Vick J. A., Mehlman B., Heiffer M. H. Early histamine release and death due to endotoxin. Proc Soc Exp Biol Med. 1971 Jul;137(3):902–906. doi: 10.3181/00379727-137-35690. [DOI] [PubMed] [Google Scholar]
  22. WATON N. G. HISTAMINE METABOLISM IN FOETAL AND VERY YOUNG CATS. J Physiol. 1963 Dec;169:919–923. doi: 10.1113/jphysiol.1963.sp007304. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. WATON N. G. Studies on mammalian histidine decarboxylase. Br J Pharmacol Chemother. 1956 Jun;11(2):119–127. doi: 10.1111/j.1476-5381.1956.tb01039.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. WATON N. G. UPTAKE AND FORMATION OF HISTAMINE BY CAT TISSUES. J Physiol. 1964 Aug;172:475–481. doi: 10.1113/jphysiol.1964.sp007433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Wallenstein S., Zucker C. L., Fleiss J. L. Some statistical methods useful in circulation research. Circ Res. 1980 Jul;47(1):1–9. doi: 10.1161/01.res.47.1.1. [DOI] [PubMed] [Google Scholar]

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