Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1987 Jan;90(1):239–246. doi: 10.1111/j.1476-5381.1987.tb16845.x

Nicotine cue in rats: effects of central administration of ganglion-blocking drugs.

R Kumar, C Reavill, I P Stolerman
PMCID: PMC1917277  PMID: 2880625

Abstract

In rats trained to discriminate nicotine from saline, a single intraventricular injection of a small dose of the quaternary ganglion-blocking drug chlorisondamine blocked the response to nicotine for four weeks. pentolinium was only weakly active and hexamethonium was inactive as a nicotine antagonist under the conditions used, even in doses that were just below those producing myoclonic jerks. Chlorisondamine had no blocking effect in rats trained to discriminate the non-nicotinic drugs midazolam or morphine from saline. Intraventricular injections of chlorisondamine have a specific and unusually persistent nicotine-blocking action, the mechanism of which requires further investigation.

Full text

PDF
239

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aceto M. D., Bentley H. C., Dembinski J. R. Effects of ganglion blocking agents on nicotine extensor convulsions and lethality in mice. Br J Pharmacol. 1969 Sep;37(1):104–111. doi: 10.1111/j.1476-5381.1969.tb09527.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Caulfield M. P., Higgins G. A. Mediation of nicotine-induced convulsions by central nicotinic receptors of the 'C6' type. Neuropharmacology. 1983 Mar;22(3):347–351. doi: 10.1016/0028-3908(83)90251-4. [DOI] [PubMed] [Google Scholar]
  3. Chance W. T., Kallman M. D., Rosecrans J. A., Spencer R. M. A comparison of nicotine and structurally related compounds as discriminative stimuli. Br J Pharmacol. 1978 Aug;63(4):609–616. doi: 10.1111/j.1476-5381.1978.tb17273.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Clarke P. B. Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. Br J Pharmacol. 1984 Oct;83(2):527–535. doi: 10.1111/j.1476-5381.1984.tb16517.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Clarke P. B., Kumar R. Characterization of the locomotor stimulant action of nicotine in tolerant rats. Br J Pharmacol. 1983 Nov;80(3):587–594. doi: 10.1111/j.1476-5381.1983.tb10733.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Colpaert F. C., Niemegeers C. J., Janssen P. A. Differential haloperidol effect on two indices of fentanyl-saline discrimination. Psychopharmacology (Berl) 1977 Jul 18;53(2):169–173. doi: 10.1007/BF00426488. [DOI] [PubMed] [Google Scholar]
  7. Garcha H. S., Rose I. C., Stolerman I. P. Midazolam cue in rats: generalization tests with anxiolytic and other drugs. Psychopharmacology (Berl) 1985;87(2):233–237. doi: 10.1007/BF00431814. [DOI] [PubMed] [Google Scholar]
  8. Hazell P., Peterson D. W., Laverty R. Brief communication. Inability of hexamethonium to block the discriminative stimulus (SD) property of nicotine. Pharmacol Biochem Behav. 1978 Jul;9(1):137–140. doi: 10.1016/0091-3057(78)90025-4. [DOI] [PubMed] [Google Scholar]
  9. Locke K. W., Holtzman S. G. Characterization of the discriminative stimulus effects of centrally administered morphine in the rat. Psychopharmacology (Berl) 1985;87(1):1–6. doi: 10.1007/BF00431767. [DOI] [PubMed] [Google Scholar]
  10. McMillan D. E., Wenger G. R. Bias of phencyclidine discrimination by the schedule of reinforcement. J Exp Anal Behav. 1984 Jul;42(1):51–66. doi: 10.1901/jeab.1984.42-51. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Meltzer L. T., Rosecrans J. A. Discriminative stimulus properties of arecoline: a new approach for studying central muscarinic receptors. Psychopharmacology (Berl) 1981;75(4):383–387. doi: 10.1007/BF00435858. [DOI] [PubMed] [Google Scholar]
  12. Morrison C. F., Stephenson J. A. Nicotine injections as the conditioned stimulus in discrimination learning. Psychopharmacologia. 1969;15(5):351–360. doi: 10.1007/BF00403710. [DOI] [PubMed] [Google Scholar]
  13. Overton D. A. Test for a neurochemically specific mechanism mediating drug discriminations and for stimulus masking. Psychopharmacology (Berl) 1983;81(4):340–344. doi: 10.1007/BF00427574. [DOI] [PubMed] [Google Scholar]
  14. Poling A. D., White F. J., Appel J. B. Discriminative stimulus properties of phencyclidine. Neuropharmacology. 1979 May;18(5):459–463. doi: 10.1016/0028-3908(79)90070-4. [DOI] [PubMed] [Google Scholar]
  15. Pratt J. A., Stolerman I. P., Garcha H. S., Giardini V., Feyerabend C. Discriminative stimulus properties of nicotine: further evidence for mediation at a cholinergic receptor. Psychopharmacology (Berl) 1983;81(1):54–60. doi: 10.1007/BF00439274. [DOI] [PubMed] [Google Scholar]
  16. Reavill C., Stolerman I. P., Kumar R., Garcha H. S. Chlorisondamine blocks acquisition of the conditioned taste aversion produced by (-)-nicotine. Neuropharmacology. 1986 Sep;25(9):1067–1069. doi: 10.1016/0028-3908(86)90204-2. [DOI] [PubMed] [Google Scholar]
  17. Romano C., Goldstein A., Jewell N. P. Characterization of the receptor mediating the nicotine discriminative stimulus. Psychopharmacology (Berl) 1981;74(4):310–315. doi: 10.1007/BF00432737. [DOI] [PubMed] [Google Scholar]
  18. Romano C., Goldstein A. Stereospecific nicotine receptors on rat brain membranes. Science. 1980 Nov 7;210(4470):647–650. doi: 10.1126/science.7433991. [DOI] [PubMed] [Google Scholar]
  19. Shannon H. E., Holtzman S. G. Evaluation of the discriminative effects of morphine in the rat. J Pharmacol Exp Ther. 1976 Jul;198(1):54–65. [PubMed] [Google Scholar]
  20. Sloan J. W., Todd G. D., Martin W. R. Nature of nicotine binding to rat brain P2 fraction. Pharmacol Biochem Behav. 1984 Jun;20(6):899–909. doi: 10.1016/0091-3057(84)90015-7. [DOI] [PubMed] [Google Scholar]
  21. Stolerman I. P., Garcha H. S., Pratt J. A., Kumar R. Role of training dose in discrimination of nicotine and related compounds by rats. Psychopharmacology (Berl) 1984;84(3):413–419. doi: 10.1007/BF00555223. [DOI] [PubMed] [Google Scholar]
  22. Stolerman I. P., Pratt J. A., Garcha H. S., Giardini V., Kumar R. Nicotine cue in rats analysed with drugs acting on cholinergic and 5-hydroxytryptamine mechanisms. Neuropharmacology. 1983 Sep;22(9):1029–1037. doi: 10.1016/0028-3908(83)90021-7. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES