Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1990 Feb;99(2):340–342. doi: 10.1111/j.1476-5381.1990.tb14705.x

Effect of neuropeptide Y on cardiac output, its distribution, regional blood flow and organ vascular resistances in the pithed rat.

M R MacLean 1, C R Hiley 1
PMCID: PMC1917380  PMID: 2328398

Abstract

1. The effects of neuropeptide Y on cardiac output, its distribution and organ vascular resistances were determined with tracer microspheres in pithed rats. 2. Neuropeptide Y increased blood pressure by increasing both cardiac output and total peripheral resistance. The increase in cardiac output was due to an increase in stroke volume as heart rate was not changed. Increased vascular resistance in the splenic, renal, testicular, epididymal, skeletal muscle, large intestinal and mesenteric vascular beds contributed to the increase in total peripheral resistance. Vasoconstriction was most pronounced in the mesenteric bed. 3. This study indicates that neuropeptide Y increases blood pressure by increasing cardiac output and total peripheral resistance. The increased cardiac output is possibly due to an increase in venous return, whilst the increased total peripheral resistance was due to regional vasoconstriction, particularly in the mesenteric bed.

Full text

PDF
340

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen J. M., Bircham P. M., Edwards A. V., Tatemoto K., Bloom S. R. Neuropeptide Y (NPY) reduces myocardial perfusion and inhibits the force of contraction of the isolated perfused rabbit heart. Regul Pept. 1983 Jul;6(3):247–253. doi: 10.1016/0167-0115(83)90143-x. [DOI] [PubMed] [Google Scholar]
  2. Dahlöf C., Dahlöf P., Lundberg J. M. Neuropeptide Y (NPY): enhancement of blood pressure increase upon alpha-adrenoceptor activation and direct pressor effects in pithed rats. Eur J Pharmacol. 1985 Feb 26;109(2):289–292. doi: 10.1016/0014-2999(85)90433-9. [DOI] [PubMed] [Google Scholar]
  3. Daly R. N., Hieble J. P. Neuropeptide Y modulates adrenergic neurotransmission by an endothelium dependent mechanism. Eur J Pharmacol. 1987 Jun 26;138(3):445–446. doi: 10.1016/0014-2999(87)90486-9. [DOI] [PubMed] [Google Scholar]
  4. Gardiner S. M., Bennett T., Compton A. M. Regional haemodynamic effects of neuropeptide Y, vasopressin and angiotensin II in conscious, unrestrained, Long Evans and Brattleboro rats. J Auton Nerv Syst. 1988 Sep;24(1-2):15–27. doi: 10.1016/0165-1838(88)90131-2. [DOI] [PubMed] [Google Scholar]
  5. Gardiner S. M., Compton A. M., Bennett T. Regional hemodynamic effects of endothelin-1 in conscious, unrestrained, Wistar rats. J Cardiovasc Pharmacol. 1989;13 (Suppl 5):S202–S204. doi: 10.1097/00005344-198900135-00057. [DOI] [PubMed] [Google Scholar]
  6. Han S. P., Trapani A. J., Fok K. F., Westfall T. C., Knuepfer M. M. Effects of endothelin on regional hemodynamics in conscious rats. Eur J Pharmacol. 1989 Jan 17;159(3):303–305. doi: 10.1016/0014-2999(89)90162-3. [DOI] [PubMed] [Google Scholar]
  7. Hiley C. R., Thomas G. R. Effects of alpha-adrenoceptor agonists on cardiac output and its regional distribution in the pithed rat. Br J Pharmacol. 1987 Jan;90(1):61–70. doi: 10.1111/j.1476-5381.1987.tb16825.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hock C. E., Passmore J. C., Levin J. I., Neiberger R. E. Angiotensin II and alpha-adrenergic control of the intrarenal circulation in hemorrhage. Circ Shock. 1982;9(1):81–94. [PubMed] [Google Scholar]
  9. Lundberg J. M., Saria A., Anggård A., Hökfelt T., Terenius L. Neuropeptide Y and noradrenaline interaction in peripheral cardiovascular control. Clin Exp Hypertens A. 1984;6(10-11):1961–1972. doi: 10.3109/10641968409046110. [DOI] [PubMed] [Google Scholar]
  10. Lundberg J. M., Terenius L., Hökfelt T., Goldstein M. High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man. Neurosci Lett. 1983 Dec 2;42(2):167–172. doi: 10.1016/0304-3940(83)90401-9. [DOI] [PubMed] [Google Scholar]
  11. MacLean M. R., Hiley C. R. Effect of artificial respiratory volume on the cardiovascular responses to an alpha 1- and an alpha 2-adrenoceptor agonist in the air-ventilated pithed rat. Br J Pharmacol. 1988 Apr;93(4):781–790. doi: 10.1111/j.1476-5381.1988.tb11463.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MacLean M. R., Hiley C. R. Effects of enalapril on changes in cardiac output and organ vascular resistances induced by alpha 1- and alpha 2-adrenoceptor agonists in pithed normotensive rats. Br J Pharmacol. 1988 Jun;94(2):449–462. doi: 10.1111/j.1476-5381.1988.tb11547.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. MacLean M. R., Randall M. D., Hiley C. R. Effects of moderate hypoxia, hypercapnia and acidosis on haemodynamic changes induced by endothelin-1 in the pithed rat. Br J Pharmacol. 1989 Nov;98(3):1055–1065. doi: 10.1111/j.1476-5381.1989.tb14638.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. MacLean M. R., Thomson M., Hiley C. R. Pressor effects of the alpha 2-adrenoceptor agonist B-HT 933 in anaesthetized and haemorrhagic rats: comparison with the haemodynamic effects of amidephrine. Br J Pharmacol. 1989 Jun;97(2):419–432. doi: 10.1111/j.1476-5381.1989.tb11969.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. McDevitt D. G., Nies A. S. Simultaneous measurement of cardiac output and its distribution with microspheres in the rat. Cardiovasc Res. 1976 Jul;10(4):494–498. doi: 10.1093/cvr/10.4.494. [DOI] [PubMed] [Google Scholar]
  16. Minson R. B., McRitchie R. J., Chalmers J. P. Effects of neuropeptide Y on left ventricular function in the conscious rabbit. Clin Exp Pharmacol Physiol. 1987 Mar;14(3):263–266. doi: 10.1111/j.1440-1681.1987.tb00387.x. [DOI] [PubMed] [Google Scholar]
  17. Morris M. J., Elliott J. M., Cain M. D., Kapoor V., West M. J., Chalmers J. P. Plasma neuropeptide y levels rise in patients undergoing exercise tests for the investigation of chest pain. Clin Exp Pharmacol Physiol. 1986 May;13(5):437–440. doi: 10.1111/j.1440-1681.1986.tb00923.x. [DOI] [PubMed] [Google Scholar]
  18. Pernow J., Saria A., Lundberg J. M. Mechanisms underlying pre- and postjunctional effects of neuropeptide Y in sympathetic vascular control. Acta Physiol Scand. 1986 Feb;126(2):239–249. doi: 10.1111/j.1748-1716.1986.tb07811.x. [DOI] [PubMed] [Google Scholar]
  19. Revington M. L., McCloskey D. I., Potter E. K. Effects of neuropeptide Y on the pressor responses to phenylephrine and to activation of the sympathetic nervous system in anaesthetized rats. Clin Exp Pharmacol Physiol. 1987 Sep;14(9):703–710. doi: 10.1111/j.1440-1681.1987.tb01895.x. [DOI] [PubMed] [Google Scholar]
  20. Tatemoto K. Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci U S A. 1982 Sep;79(18):5485–5489. doi: 10.1073/pnas.79.18.5485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Westfall T. C., Carpentier S., Chen X., Beinfeld M. C., Naes L., Meldrum M. J. Prejunctional and postjunctional effects of neuropeptide Y at the noradrenergic neuroeffector junction of the perfused mesenteric arterial bed of the rat. J Cardiovasc Pharmacol. 1987 Dec;10(6):716–722. doi: 10.1097/00005344-198712000-00016. [DOI] [PubMed] [Google Scholar]
  22. Yanagisawa M., Kurihara H., Kimura S., Tomobe Y., Kobayashi M., Mitsui Y., Yazaki Y., Goto K., Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988 Mar 31;332(6163):411–415. doi: 10.1038/332411a0. [DOI] [PubMed] [Google Scholar]
  23. Zukowska-Grojec Z., Marks E. S., Haass M. Neuropeptide Y is a potent vasoconstrictor and a cardiodepressant in rat. Am J Physiol. 1987 Nov;253(5 Pt 2):H1234–H1239. doi: 10.1152/ajpheart.1987.253.5.H1234. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES