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. 1990 Feb;99(2):317–322. doi: 10.1111/j.1476-5381.1990.tb14701.x

The action of atriopeptin III on renal function in two models of chronic renal failure in the rat.

E J Johns 1, B Rutkowski 1
PMCID: PMC1917403  PMID: 2139350

Abstract

1. The natriuretic and diuretic effects of atriopeptin III (125, 250 and 500 ng kg-1, i.v.) were studied in groups of rats anaesthetized with pentobarbitone which were either sham controls, unilaterally nephrectomized controls, adenine-fed or subtotal nephrectomy chronic renal failure models. 2. Atriopeptin III given at these doses to the sham control animals had no effect on blood pressure, renal blood flow or glomerular filtration rate but reversibly increased urine flow, between 46% to 54%, absolute sodium excretion, between 52% to 61%, and fractional sodium excretion, between 48% to 54% (all P values less than 0.05) from the lowest to the highest dose. The adenine-fed chronic renal failure group of rats had a reduced renal blood flow of between 30 and 75%, and glomerular filtration rate of approximately 20%, compared to the sham controls. Administration of atriopeptin at 125, 250 and 500 ng kg-1 to the animals with renal failure increased water and sodium excretion to the same degree as observed in the sham group of rats. 3. In the group of unilaterally nephrectomized rats, atriopeptin III, at 125, 250 and 500 ng kg-1 increased urine flow by 36%, 47% and 72%, respectively, absolute sodium excretion by 37%, 57% and 106%, respectively, and fractional sodium excretion by 46%, 45% and 102%, respectively. A similar pattern of responses was observed in the subtotal nephrectomy, chronic renal failure group in which filtration rate was approximately 4 times less than the controls.(ABSTRACT TRUNCATED AT 250 WORDS)

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Selected References

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  1. Anderson J. V., Raine A. E., Proudler A., Bloom S. R. Effect of haemodialysis on plasma concentrations of atrial natriuretic peptide in adult patients with chronic renal failure. J Endocrinol. 1986 Aug;110(2):193–196. doi: 10.1677/joe.0.1100193. [DOI] [PubMed] [Google Scholar]
  2. Goetz K. L. Physiology and pathophysiology of atrial peptides. Am J Physiol. 1988 Jan;254(1 Pt 1):E1–15. doi: 10.1152/ajpendo.1988.254.1.E1. [DOI] [PubMed] [Google Scholar]
  3. Hildebrandt D. A., Banks R. O. Effect of atrial natriuretic factor on renal function in rats with nephrotic syndrome. Am J Physiol. 1988 Feb;254(2 Pt 2):F210–F216. doi: 10.1152/ajprenal.1988.254.2.F210. [DOI] [PubMed] [Google Scholar]
  4. Hintze T. H., Currie M. G., Needleman P. Atriopeptins: renal-specific vasodilators in conscious dogs. Am J Physiol. 1985 Apr;248(4 Pt 2):H587–H591. doi: 10.1152/ajpheart.1985.248.4.H587. [DOI] [PubMed] [Google Scholar]
  5. Hostetter T. H., Olson J. L., Rennke H. G., Venkatachalam M. A., Brenner B. M. Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. Am J Physiol. 1981 Jul;241(1):F85–F93. doi: 10.1152/ajprenal.1981.241.1.F85. [DOI] [PubMed] [Google Scholar]
  6. Johns E. J. A study of the renal actions of amlodipine in the normotensive and spontaneously hypertensive rat. Br J Pharmacol. 1988 Jun;94(2):311–318. doi: 10.1111/j.1476-5381.1988.tb11532.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Johns E. J., Lewis B. A., Singer B. The sodium-retaining effect of renal nerve activity in the cat: role of angiotensin formation. Clin Sci Mol Med. 1976 Jul;51(1):93–102. doi: 10.1042/cs0510093. [DOI] [PubMed] [Google Scholar]
  8. Johns E. J., Rutkowski B. A comparison of the action of atriopeptin III on renal function in normal and DOCA-salt hypertensive rats. J Hypertens. 1989 Aug;7(8):675–682. doi: 10.1097/00004872-198908000-00012. [DOI] [PubMed] [Google Scholar]
  9. Kohno M., Yasunari K., Matsuura T., Murakawa K., Takeda T. Circulating atrial natriuretic polypeptide in essential hypertension. Am Heart J. 1987 May;113(5):1160–1163. doi: 10.1016/0002-8703(87)90929-x. [DOI] [PubMed] [Google Scholar]
  10. Luft F. C., Lang R. E., Aronoff G. R., Ruskoaho H., Toth M., Ganten D., Sterzel R. B., Unger T. Atriopeptin III kinetics and pharmacodynamics in normal and anephric rats. J Pharmacol Exp Ther. 1986 Feb;236(2):416–418. [PubMed] [Google Scholar]
  11. Luft F. C., Sterzel R. B., Lang R. E., Trabold E. M., Veelken R., Ruskoaho H., Gao Y., Ganten D., Unger T. Atrial natriuretic factor determinations and chronic sodium homeostasis. Kidney Int. 1986 May;29(5):1004–1010. doi: 10.1038/ki.1986.100. [DOI] [PubMed] [Google Scholar]
  12. Matsubara H., Umeda Y., Yamane Y., Nishikawa M., Taniguchi T., Inada M. Role of atrial natriuretic polypeptides for exaggerated natriuresis in essential hypertension. Am J Cardiol. 1987 Sep 15;60(8):708–714. doi: 10.1016/0002-9149(87)90387-0. [DOI] [PubMed] [Google Scholar]
  13. Predel H. G., Bäcker A., Kipnowski J., Düsing R., Kramer H. J. Relationship of plasma concentrations of human atrial natriuretic peptide to renal function and blood pressure in patients with progressive chronic renal failure. Klin Wochenschr. 1987;65 (Suppl 8):127–132. [PubMed] [Google Scholar]
  14. Raine A. E., Firth J. G., Ledingham J. G. Renal actions of atrial natriuretic factor. Clin Sci (Lond) 1989 Jan;76(1):1–8. doi: 10.1042/cs0760001. [DOI] [PubMed] [Google Scholar]
  15. Rutkowski B., Hoppe A., Manitius A., Angielski S. Blood glucose and insulin levels following glucose load in rats with chronic renal insufficiency. Acta Med Pol. 1981;22(3):199–206. [PubMed] [Google Scholar]
  16. Saito H., Ogihara T., Nakamaru M., Hara H., Higaki J., Rakugi H., Tateyama H., Minamino T., Iinuma K., Kumahara Y. Hemodynamic, renal, and hormonal responses to alpha-human atrial natriuretic peptide in patients with congestive heart failure. Clin Pharmacol Ther. 1987 Aug;42(2):142–147. doi: 10.1038/clpt.1987.124. [DOI] [PubMed] [Google Scholar]
  17. Schnermann J., Briggs J. P. Renal effects of atrial natriuretic peptides. Klin Wochenschr. 1987;65 (Suppl 8):92–96. [PubMed] [Google Scholar]
  18. Sterzel R. B., Luft F. C., Lang R. E., Ganten D. Effects of atrial natriuretic factor in rats with renal insufficiency. J Lab Clin Med. 1987 Jul;110(1):63–69. [PubMed] [Google Scholar]
  19. Vinay P., Manillier C., Lalonde L., Thibault G., Boulanger Y., Gougoux A., Cantin M. Comparative effect of ANF and various diuretics on isolated nephron segments. Kidney Int. 1987 Apr;31(4):946–955. doi: 10.1038/ki.1987.91. [DOI] [PubMed] [Google Scholar]
  20. Yokozawa T., Zheng P. D., Oura H., Koizumi F. Animal model of adenine-induced chronic renal failure in rats. Nephron. 1986;44(3):230–234. doi: 10.1159/000183992. [DOI] [PubMed] [Google Scholar]

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