Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1990 May;100(1):126–130. doi: 10.1111/j.1476-5381.1990.tb12063.x

The effects of cholecystokinin octapeptide on human isolated alimentary muscle.

M D'Amato 1, I F Stamford 1, A Bennett 1
PMCID: PMC1917477  PMID: 2372654

Abstract

1. We studied cholecystokinin octapeptide (CCK-OP) for its motor effects and sites of action on human isolated muscle from stomach, small intestine and colon. 2. CCK-OP induced a concentration-dependent contraction of all the longitudinal muscles and of circular muscle from the stomach and large intestine. The peptide acted directly on these muscles at a site not involving muscarinic receptors. 3. CCK-OP relaxed the circular muscle of the small intestine and/or reduced the contractions to acetylcholine, by stimulating intramural postganglionic inhibitory neurones.

Full text

PDF
126

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Behar J., Biancani P. Effect of cholecystokinin and the octapeptide of cholecystokinin on the feline sphincter of Oddi and gallbladder. Mechanisms of action. J Clin Invest. 1980 Dec;66(6):1231–1239. doi: 10.1172/JCI109974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bennett A., Bloom S. R., Ch'ng J., Christofides N. D., Peacock L. E., Rennie J. A. Is vasoactive intestinal peptide an inhibitory transmitter in the circular but not the longitudinal muscle of guinea-pig colon? J Pharm Pharmacol. 1984 Nov;36(11):787–788. doi: 10.1111/j.2042-7158.1984.tb04877.x. [DOI] [PubMed] [Google Scholar]
  3. Bennett A., Murray J. G., Wyllie J. H. Occurrence of prostaglandin E2 in the human stomach, and a study of its effects on human isolated gastric muscle. Br J Pharmacol Chemother. 1968 Feb;32(2):339–349. [PubMed] [Google Scholar]
  4. Bennett A. Relationship between in-vitro studies of gastrointestinal muscle and motility of the alimentary tract in vivo. Am J Dig Dis. 1968 May;13(5):410–414. doi: 10.1007/BF02233658. [DOI] [PubMed] [Google Scholar]
  5. Bennett A., Whitney B. A pharmacological investigation of human isolated stomach. Br J Pharmacol Chemother. 1966 Aug;27(2):286–298. doi: 10.1111/j.1476-5381.1966.tb01663.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bennett A., Whitney B. A pharmacological study of the motility of the human gastrointestinal tract. Gut. 1966 Aug;7(4):307–316. doi: 10.1136/gut.7.4.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Black J. W., Leff P., Shankley N. P. Further analysis of anomalous pKB values for histamine H2-receptor antagonists on the mouse isolated stomach assay. Br J Pharmacol. 1985 Nov;86(3):581–587. doi: 10.1111/j.1476-5381.1985.tb08934.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cameron A. J., Phillips S. F., Summerskill W. H. Comparison of effects of gastrin, cholecystokinin-pancreozymin, secretin, and glucagon on human stomach muscle in vitro. Gastroenterology. 1970 Oct;59(4):539–545. [PubMed] [Google Scholar]
  9. Dinoso V. P., Jr, Meshkinpour H., Lorber S. H., Gutierrez J. G., Chey W. Y. Motor responses of the sigmoid colon and rectum to exogenous cholecystokinin and secretin. Gastroenterology. 1973 Sep;65(3):438–444. [PubMed] [Google Scholar]
  10. Egberts E. H., Johnson A. G. The effect of cholecystokinin on human taenia coli. Digestion. 1977;15(3):217–222. doi: 10.1159/000198005. [DOI] [PubMed] [Google Scholar]
  11. Fried G. M., Ogden W. D., Swierczek J., Greeley G. H., Jr, Rayford P. L., Thompson J. C. Release of cholecystokinin in conscious dogs: correlation with simultaneous measurements of gallbladder pressure and pancreatic protein secretion. Gastroenterology. 1983 Nov;85(5):1113–1119. [PubMed] [Google Scholar]
  12. Gerner T., Haffner J. F. The role of local cholinergic pathways in the motor response to cholecystokinin and gastrin in isolated guinea-pig fundus and antrum. Scand J Gastroenterol. 1977;12(6):751–757. doi: 10.3109/00365527709181715. [DOI] [PubMed] [Google Scholar]
  13. Grider J. R., Makhlouf G. M. Regional and cellular heterogeneity of cholecystokinin receptors mediating muscle contraction in the gut. Gastroenterology. 1987 Jan;92(1):175–180. doi: 10.1016/0016-5085(87)90855-9. [DOI] [PubMed] [Google Scholar]
  14. Hutchison J. B., Dockray G. J. Evidence that the action of cholecystokinin octapeptide on the guinea pig ileum longitudinal muscle is mediated in part by substance P release from the myenteric plexus. Eur J Pharmacol. 1981 Jan 5;69(1):87–93. doi: 10.1016/0014-2999(81)90605-1. [DOI] [PubMed] [Google Scholar]
  15. Hutchison J. B., Dockray G. J. Inhibition of the action of cholecystokinin octapeptide on the guinea pig ileum myenteric plexus by dibutyryl cyclic guanosine monophosphate. Brain Res. 1980 Dec 8;202(2):501–505. doi: 10.1016/0006-8993(80)90164-x. [DOI] [PubMed] [Google Scholar]
  16. Kellow J. E., Miller L. J., Phillips S. F., Haddad A. C., Zinsmeister A. R., Charboneau J. W. Sensitivities of human jejunum, ileum, proximal colon, and gallbladder to cholecystokinin octapeptide. Am J Physiol. 1987 Mar;252(3 Pt 1):G345–G356. doi: 10.1152/ajpgi.1987.252.3.G345. [DOI] [PubMed] [Google Scholar]
  17. Lüdtke F. E., Golenhofen K., Köhne C. Direct effects of cholecystokinin on human gastric motility. Digestion. 1988;39(4):210–218. doi: 10.1159/000199628. [DOI] [PubMed] [Google Scholar]
  18. Morgan K. G., Schmalz P. F., Go V. L., Szurszewski J. H. Electrical and mechanical effects of molecular variants of CCK on antral smooth muscle. Am J Physiol. 1978 Sep;235(3):E324–E329. doi: 10.1152/ajpendo.1978.235.3.E324. [DOI] [PubMed] [Google Scholar]
  19. Schmalz P. F., Morgan K. G., Szurszewski J. H. Pentagastrin potentiates nonadrenergic inhibitory neuromuscular transmission in orad stomach of the dog. Am J Physiol. 1983 Oct;245(4):G597–G600. doi: 10.1152/ajpgi.1983.245.4.G597. [DOI] [PubMed] [Google Scholar]
  20. Vizi E. S., Bertaccini G., Impicciatore M., Knoll J. Acetylcholine-releasing effect of gastrin and related polypeptides. Eur J Pharmacol. 1972 Jan;17(1):175–178. doi: 10.1016/0014-2999(72)90286-5. [DOI] [PubMed] [Google Scholar]
  21. Vizi S. E., Bertaccini G., Impicciatore M., Knoll J. Evidence that acetylcholine released by gastrin and related polypeptides contributes to their effect on gastrointestinal motility. Gastroenterology. 1973 Feb;64(2):268–277. [PubMed] [Google Scholar]
  22. Walsh J. H., Lamers C. B., Valenzuela J. E. Cholecystokinin-octapeptidelike immunoreactivity in human plasma. Gastroenterology. 1982 Mar;82(3):438–444. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES