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. 1990 Jan;99(1):164–168. doi: 10.1111/j.1476-5381.1990.tb14671.x

Differential inhibition by two hetrazepine PAF antagonists of acute inflammation in the mouse.

M G Henriques 1, V B Weg 1, M A Martins 1, P M Silva 1, P D Fernandes 1, R S Cordeiro 1, B B Vargaftig 1
PMCID: PMC1917491  PMID: 2331569

Abstract

1. The injection of 100 or 300 micrograms of carrageenin into the mouse paw or pleural cavity produced a delayed inflammatory reaction at 48 h while platelet activating factor (PAF)-induced paw oedema and pleurisy were maximal 30 min after its injection. 2. The PAF antagonist, WEB 2086, failed to inhibit mouse paw oedema and pleurisy induced by PAF, but reduced the first phase of oedema (1-4 h) induced by carrageenin without interfering with the second one (48-72 h). In contrast, another structurally-related PAF antagonist, WEB 2170, inhibited dose-dependently both oedema and pleurisy induced by PAF and by carrageenin (48 h). 3. Repeated injections of PAF into the mouse paw or pleural cavity led to significant autodesensitization. The animals desensitized to PAF and injected with carrageenin also displayed a significantly reduced oedema. 4. Our results suggest that PAF may be involved in the inflammatory response to carrageenin in mice. Furthermore, because the different receptor antagonists displayed distinct effects against PAF itself, different sites for in vivo interaction of PAF are available and are species- and drug-dependent.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Björk J., Smedegård G. Acute microvascular effects of PAF-acether, as studied by intravital microscopy. Eur J Pharmacol. 1983 Dec 9;96(1-2):87–94. doi: 10.1016/0014-2999(83)90532-0. [DOI] [PubMed] [Google Scholar]
  2. Braquet P., Touqui L., Shen T. Y., Vargaftig B. B. Perspectives in platelet-activating factor research. Pharmacol Rev. 1987 Jun;39(2):97–145. [PubMed] [Google Scholar]
  3. Casals-Stenzel J., Muacevic G., Weber K. H. Pharmacological actions of WEB 2086, a new specific antagonist of platelet activating factor. J Pharmacol Exp Ther. 1987 Jun;241(3):974–981. [PubMed] [Google Scholar]
  4. Cordeiro R. S., Martins M. A., Silva P. M., Faria Neto H. C., Castanheira J. R., Vargaftig B. B. Desensitization to PAF-induced rat paw oedema by repeated intraplantar injections. Life Sci. 1986 Nov 17;39(20):1871–1878. doi: 10.1016/0024-3205(86)90297-3. [DOI] [PubMed] [Google Scholar]
  5. Henriques M. G., Silva P. M., Martins M. A., Flores C. A., Cunha F. Q., Assreuy-Filho J., Cordeiro R. S. Mouse paw edema. A new model for inflammation? Braz J Med Biol Res. 1987;20(2):243–249. [PubMed] [Google Scholar]
  6. Humphrey D. M., McManus L. M., Satouchi K., Hanahan D. J., Pinckard R. N. Vasoactive properties of acetyl glyceryl ether phosphorylcholine and analogues. Lab Invest. 1982 Apr;46(4):422–427. [PubMed] [Google Scholar]
  7. Hwang S. B., Lam M. H., Li C. L., Shen T. Y. Release of platelet activating factor and its involvement in the first phase of carrageenin-induced rat foot edema. Eur J Pharmacol. 1986 Jan 14;120(1):33–41. doi: 10.1016/0014-2999(86)90636-9. [DOI] [PubMed] [Google Scholar]
  8. Hwang S. B., Li C. L., Lam M. H., Shen T. Y. Characterization of cutaneous vascular permeability induced by platelet-activating factor in guinea pigs and rats and its inhibition by a platelet-activating factor receptor antagonist. Lab Invest. 1985 Jun;52(6):617–630. [PubMed] [Google Scholar]
  9. Martins M. A., Silva P. M., Faria Neto H. C., Bozza P. T., Dias P. M., Lima M. C., Cordeiro R. S., Vargaftig B. B. Pharmacological modulation of Paf-induced rat pleurisy and its role in inflammation by zymosan. Br J Pharmacol. 1989 Feb;96(2):363–371. doi: 10.1111/j.1476-5381.1989.tb11826.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pirotzky E., Pfister A., Benveniste J. A role for Paf-acether (platelet-activating factor) in acute skin inflammation? Br J Dermatol. 1985 Jul;113 (Suppl 28):91–94. doi: 10.1111/j.1365-2133.1985.tb15632.x. [DOI] [PubMed] [Google Scholar]
  11. Silva P. M., Cordeiro R. S., Martins M. A., Henriques M. G., Vargaftig B. B. Platelet involvement in rat paw edema induced by 2-methoxy-PAF. Inflammation. 1986 Dec;10(4):393–401. doi: 10.1007/BF00915823. [DOI] [PubMed] [Google Scholar]
  12. Tarayre J. P., Delhon A., Bruniquel F., Puech L., Tisne-Versailles J., Couzinier J. P. Exudative, cellular and humoral reactions to platelet-activating factor (PAF-acether) in the pleural cavity of rats. Eur J Pharmacol. 1986 May 27;124(3):317–323. doi: 10.1016/0014-2999(86)90233-5. [DOI] [PubMed] [Google Scholar]
  13. Vargaftig B. B., Ferreira S. H. Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors. Braz J Med Biol Res. 1981 Jul;14(2-3):187–189. [PubMed] [Google Scholar]

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