Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1990 Aug;100(4):757–760. doi: 10.1111/j.1476-5381.1990.tb14088.x

Evidence that central 5-HT1A-receptors play a role in the von Bezold-Jarisch reflex in the rat.

R G Bogle 1, J G Pires 1, A G Ramage 1
PMCID: PMC1917580  PMID: 2207497

Abstract

1. The effects of intracisternal (i.c.) application of putative 5-hydroxytryptamine (5-HT)1A antagonists on the reflex bradycardia evoked by injection of phenylbiguanide (i.v.) were investigated in anaesthetized, atenolol-pretreated rats. 2. Intracisternal application of spiperone (100 micrograms kg-1) reversibly attenuated the reflex bradycardia whilst the same dose given i.v. had no effect. The bradycardia was also attenuated by i.c. methiothepin (200 micrograms kg-1), (+/-)-pindolol (100 micrograms kg-1) and buspirone (200 micrograms kg-1) but was not attenuated by antagonists selective for alpha 1-adrenoceptors (alfuzosin; 100 micrograms kg-1), 5-HT2-receptors (BW 501C67; 100 micrograms kg-1) or dopamine D2-receptors ((-)-sulpiride; 100 micrograms kg-1) given i.c. 3. It is concluded that the 5-HT1A-receptor antagonist action of intracisternally applied spiperone, methiothepin, (+/-)-pindolol and buspirone is responsible for the ability of these drugs to attenuate reversibly the excitation of cardiac vagal motoneurones caused by activation of the von Bezold-Jarisch reflex.

Full text

PDF
757

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bogle R. G., Ramage A. G. Evidence that the reflex vagal bradycardia caused by i.v. phenyl biguanide is mediated by central 5-HT1A receptors. Br J Pharmacol. 1989 Dec;98 (Suppl):811P–811P. [PubMed] [Google Scholar]
  2. Brown M. J., Harland D. B-HT 958 lowers blood pressure and heart rate in the rat through stimulation of dopamine receptors. Br J Pharmacol. 1986 Feb;87(2):361–370. doi: 10.1111/j.1476-5381.1986.tb10825.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CERVONI P., BERTINO J. R., GEIGER L. E. MEDULLARY VAGAL EFFECTS OF D-LYSERGIC ACID DIETHYLAMIDE IN THE DECEREBRATE CAT. Nature. 1963 Aug 17;199:700–701. doi: 10.1038/199700a0. [DOI] [PubMed] [Google Scholar]
  4. Cherqui C., Dabiré H., Fournier B., Schmitt H. Participation of sympathetic and vagal tones in the hypotensive and bradycardic effects of some 5-HT1-like receptor agonists in the rat. Arch Int Pharmacodyn Ther. 1988 Nov-Dec;296:18–28. [PubMed] [Google Scholar]
  5. DAWES G. S., MOTT J. C. Circulatory and respiratory reflexes caused by aromatic guanidines. Br J Pharmacol Chemother. 1950 Mar;5(1):65–76. doi: 10.1111/j.1476-5381.1950.tb00578.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dalton D. W. The cardiovascular effects of centrally administered 5-hydroxytryptamine in the conscious normotensive and hypertensive rat. J Auton Pharmacol. 1986 Mar;6(1):67–75. doi: 10.1111/j.1474-8673.1986.tb00632.x. [DOI] [PubMed] [Google Scholar]
  7. Direct evidence for an interaction of beta-adrenergic blockers with the 5-HT receptor. Nature. 1977 May 19;267(5608):289–290. doi: 10.1038/267289a0. [DOI] [PubMed] [Google Scholar]
  8. Feniuk W., Humphrey P. P., Perren M. J., Watts A. D. A comparison of 5-hydroxytryptamine receptors mediating contraction in rabbit aorta and dog saphenous vein: evidence for different receptor types obtained by use of selective agonists and antagonists. Br J Pharmacol. 1985 Nov;86(3):697–704. doi: 10.1111/j.1476-5381.1985.tb08948.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fozard J. R. Mechanism of the hypotensive effect of ketanserin. J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):829–838. doi: 10.1097/00005344-198209000-00020. [DOI] [PubMed] [Google Scholar]
  10. Gaudin-Chazal G., Portalier P., Barrit M. C., Puizillout J. J. Serotonin-like immunoreactivity in paraffin-sections of the nodose ganglia of the cat. Neurosci Lett. 1982 Nov 30;33(2):169–172. doi: 10.1016/0304-3940(82)90246-4. [DOI] [PubMed] [Google Scholar]
  11. Gradin K., Pettersson A., Hedner T., Persson B. Acute administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT-receptor agonist, causes a biphasic blood pressure response and a bradycardia in the normotensive Sprague-Dawley rat and in the spontaneously hypertensive rat. J Neural Transm. 1985;62(3-4):305–319. doi: 10.1007/BF01252244. [DOI] [PubMed] [Google Scholar]
  12. Hoyer D. Functional correlates of serotonin 5-HT1 recognition sites. J Recept Res. 1988;8(1-4):59–81. doi: 10.3109/10799898809048978. [DOI] [PubMed] [Google Scholar]
  13. Kalia M., Sullivan J. M. Brainstem projections of sensory and motor components of the vagus nerve in the rat. J Comp Neurol. 1982 Nov 1;211(3):248–265. doi: 10.1002/cne.902110304. [DOI] [PubMed] [Google Scholar]
  14. Katsura I. Determination of bacteriophage lambda tail length by a protein ruler. Nature. 1987 May 7;327(6117):73–75. doi: 10.1038/327073a0. [DOI] [PubMed] [Google Scholar]
  15. Mawson C., Whittington H. Evaluation of the peripheral and central antagonistic activities against 5-hydroxytryptamine of some new agents. Br J Pharmacol. 1970 May;39(1):223P–224P. [PMC free article] [PubMed] [Google Scholar]
  16. Nosaka S., Yamamoto T., Yasunaga K. Localization of vagal cardioinhibitory preganglionic neurons with rat brain stem. J Comp Neurol. 1979 Jul 1;186(1):79–92. doi: 10.1002/cne.901860106. [DOI] [PubMed] [Google Scholar]
  17. Pazos A., Cortés R., Palacios J. M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res. 1985 Nov 4;346(2):231–249. doi: 10.1016/0006-8993(85)90857-1. [DOI] [PubMed] [Google Scholar]
  18. Pazos A., Palacios J. M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 1985 Nov 4;346(2):205–230. doi: 10.1016/0006-8993(85)90856-x. [DOI] [PubMed] [Google Scholar]
  19. Pratt G. D., Bowery N. G. The 5-HT3 receptor ligand, [3H]BRL 43694, binds to presynaptic sites in the nucleus tractus solitarius of the rat. Neuropharmacology. 1989 Dec;28(12):1367–1376. doi: 10.1016/0028-3908(89)90012-9. [DOI] [PubMed] [Google Scholar]
  20. Ramage A. G., Fozard J. R. Evidence that the putative 5-HT1A receptor agonists, 8-OH-DPAT and ipsapirone, have a central hypotensive action that differs from that of clonidine in anaesthetised cats. Eur J Pharmacol. 1987 Jun 19;138(2):179–191. doi: 10.1016/0014-2999(87)90431-6. [DOI] [PubMed] [Google Scholar]
  21. Ramage A. G., Wouters W., Bevan P. Evidence that the novel antihypertensive agent, flesinoxan, causes differential sympathoinhibition and also increases vagal tone by a central action. Eur J Pharmacol. 1988 Jul 14;151(3):373–379. doi: 10.1016/0014-2999(88)90533-x. [DOI] [PubMed] [Google Scholar]
  22. Schoeffter P., Hoyer D. Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br J Pharmacol. 1988 Nov;95(3):975–985. doi: 10.1111/j.1476-5381.1988.tb11728.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Sprouse J. S., Aghajanian G. K. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse. 1987;1(1):3–9. doi: 10.1002/syn.890010103. [DOI] [PubMed] [Google Scholar]
  24. Steinbusch H. W. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience. 1981;6(4):557–618. doi: 10.1016/0306-4522(81)90146-9. [DOI] [PubMed] [Google Scholar]
  25. Stoof J. C., Kebabian J. W. Two dopamine receptors: biochemistry, physiology and pharmacology. Life Sci. 1984 Dec 3;35(23):2281–2296. doi: 10.1016/0024-3205(84)90519-8. [DOI] [PubMed] [Google Scholar]
  26. Street J. A., Hemsworth B. A., Roach A. G., Day M. D. Tissue levels of several radiolabelled beta-adrenoceptor antagonists after intravenous administration in rats. Arch Int Pharmacodyn Ther. 1979 Feb;237(2):180–190. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES