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. 1991 Mar;102(3):573–576. doi: 10.1111/j.1476-5381.1991.tb12214.x

Prejunctional prostanoid receptors on cardiac adrenergic terminals belong to the EP3 subtype.

L Mantelli 1, S Amerini 1, A Rubino 1, F Ledda 1
PMCID: PMC1917961  PMID: 1364821

Abstract

1. The effects of prostaglandin E2 (PGE2) and of several synthetic prostanoids on the cardiac response to sympathetic nerve stimulation in guinea-pig atria have been evaluated. 2. PGE2 (0.01-100 nM), sulprostone (0.01-100 nM) and misoprostol (0.1-100 nM), but not butaprost (0.1-100 nM), dose-dependently reduced the increase in cardiac contractility induced by electrical field stimulation of sympathetic terminals. 3. The EP1 antagonist AH6809 (1 microM) did not modify the inhibition of cardiac response induced by PGE2, sulprostone and misoprostol. 4. In preparations preloaded with [3H]-noradrenaline, tritium overflow induced by electrical field stimulation was greatly and significantly reduced by 100 nM PGE2 and by 100 nM sulprostone. 5. These results indicate that PGE2 and other synthetic prostanoids reduce noradrenaline release from cardiac adrenergic nerve terminals acting on prejunctional inhibitory receptors belonging to the EP3 subtype.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ambache N., Zar M. A. An inhibitory effect of prostaglandin E2 on neuromuscular transmission in the guinea-pig vas deferens. J Physiol. 1970 May;208(1):30P–32P. [PubMed] [Google Scholar]
  2. Fuder H., Muscholl E. The effect of methacholine on noradrenaline release from the rabbit heart perfused with indometacin. Naunyn Schmiedebergs Arch Pharmacol. 1974;285(2):127–132. doi: 10.1007/BF00501148. [DOI] [PubMed] [Google Scholar]
  3. Hedqvist P. Basic mechanisms of prostaglandin action on autonomic neurotransmission. Annu Rev Pharmacol Toxicol. 1977;17:259–279. doi: 10.1146/annurev.pa.17.040177.001355. [DOI] [PubMed] [Google Scholar]
  4. Hedqvist P., Stjärne L., Wennmalm A. Inhibition by prostaglandin E2 of sympathetic neurotransmission in the rabbit heart. Acta Physiol Scand. 1970 May;79(1):139–141. doi: 10.1111/j.1748-1716.1970.tb04712.x. [DOI] [PubMed] [Google Scholar]
  5. Hedqvist P., Von Euler U. S. Prostaglandin-induced neurotransmission failure in the field-stimulated, isolated vas deferens. Neuropharmacology. 1972 Mar;11(2):177–187. doi: 10.1016/0028-3908(72)90090-1. [DOI] [PubMed] [Google Scholar]
  6. Khan M. T., Malik K. U. Modulation by prostaglandins of the release of [3H] noradrenaline evoked by potassium and nerve stimulation in the isolated rat heart. Eur J Pharmacol. 1982 Feb 26;78(2):213–218. doi: 10.1016/0014-2999(82)90238-2. [DOI] [PubMed] [Google Scholar]
  7. Khan M. T., Malik K. U. Sympathetic nerve stimulation of the isolated rat heart: release of prostaglandin-like substance and the inhibitory effect of prostacyclin on the output of [3H]-norepinephrine. Adv Prostaglandin Thromboxane Res. 1980;8:1241–1243. [PubMed] [Google Scholar]
  8. Ledda F., Mantelli L. Differences between the prejunctional effects of phenylephrine and clonidine in guinea-pig isolated atria. Br J Pharmacol. 1984 Mar;81(3):491–497. doi: 10.1111/j.1476-5381.1984.tb10102.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Malik K. U. Prostaglandins--modulation of adrenergic nervous system. Fed Proc. 1978 Feb;37(2):203–207. [PubMed] [Google Scholar]
  10. Mantelli L., Amerini S., Ledda F. Different effects of prostaglandins on adrenergic neurotransmission in atrial and ventricular preparations. Br J Pharmacol. 1990 Apr;99(4):717–720. doi: 10.1111/j.1476-5381.1990.tb12995.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Marques M. C., Ladosky E. M., Fonteles M. C. The presynaptic effects of aspirin and prostaglandin E2 in the isolated cat heart. Braz J Med Biol Res. 1983 Jul;16(2):133–140. [PubMed] [Google Scholar]
  12. McKenniff M., Rodger I. W., Norman P., Gardiner P. J. Characterisation of receptors mediating the contractile effects of prostanoids in guinea-pig and human airways. Eur J Pharmacol. 1988 Aug 24;153(2-3):149–159. doi: 10.1016/0014-2999(88)90601-2. [DOI] [PubMed] [Google Scholar]
  13. Wennmalm A. Studies on mechanisms controlling the secretion of neurotransmitters in the rabbit heart. Acta Physiol Scand Suppl. 1971;365:1–36. [PubMed] [Google Scholar]
  14. Williams T. L., Smith D. A., Burton N. R., Stone T. W. Amino acid pharmacology in neocortical slices: evidence for bimolecular actions from an extension of the Hill and Gaddum-Schild equations. Br J Pharmacol. 1988 Nov;95(3):805–810. doi: 10.1111/j.1476-5381.1988.tb11708.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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