Abstract
Pinacidil, a potassium-channel opener, inhibited the ryanodine-sensitive oscillatory outward potassium current induced by Ca released from an intracellular store. Glibenclamide, a blocker of the ATP-sensitive K-channel, prevented the action of pinacidil, suggesting the presence of an additional site (to K channels) for the vasodilator actions of pinacidil at which glibenclamide can act as an antagonist.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bolton T. B., Lim S. P. Properties of calcium stores and transient outward currents in single smooth muscle cells of rabbit intestine. J Physiol. 1989 Feb;409:385–401. doi: 10.1113/jphysiol.1989.sp017504. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fan Z., Nakayama K., Hiraoka M. Pinacidil activates the ATP-sensitive K+ channel in inside-out and cell-attached patch membranes of guinea-pig ventricular myocytes. Pflugers Arch. 1990 Jan;415(4):387–394. doi: 10.1007/BF00373613. [DOI] [PubMed] [Google Scholar]
- Kajioka S., Oike M., Kitamura K. Nicorandil opens a calcium-dependent potassium channel in smooth muscle cells of the rat portal vein. J Pharmacol Exp Ther. 1990 Sep;254(3):905–913. [PubMed] [Google Scholar]
- Ohya Y., Kitamura K., Kuriyama H. Cellular calcium regulates outward currents in rabbit intestinal smooth muscle cell. Am J Physiol. 1987 Apr;252(4 Pt 1):C401–C410. doi: 10.1152/ajpcell.1987.252.4.C401. [DOI] [PubMed] [Google Scholar]
- Ohya Y., Terada K., Yamaguchi K., Inoue R., Okabe K., Kitamura K., Hirata M., Kuriyama H. Effects of inositol phosphates on the membrane activity of smooth muscle cells of the rabbit portal vein. Pflugers Arch. 1988 Sep;412(4):382–389. doi: 10.1007/BF01907556. [DOI] [PubMed] [Google Scholar]
- Okabe K., Kajioka S., Nakao K., Kitamura K., Kuriyama H., Weston A. H. Actions of cromakalim on ionic currents recorded from single smooth muscle cells of the rat portal vein. J Pharmacol Exp Ther. 1990 Feb;252(2):832–839. [PubMed] [Google Scholar]
- Sakai T., Terada K., Kitamura K., Kuriyama H. Ryanodine inhibits the Ca-dependent K current after depletion of Ca stored in smooth muscle cells of the rabbit ileal longitudinal muscle. Br J Pharmacol. 1988 Dec;95(4):1089–1100. doi: 10.1111/j.1476-5381.1988.tb11743.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Standen N. B., Quayle J. M., Davies N. W., Brayden J. E., Huang Y., Nelson M. T. Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle. Science. 1989 Jul 14;245(4914):177–180. doi: 10.1126/science.2501869. [DOI] [PubMed] [Google Scholar]
- de Weille J. R., Lazdunski M. Regulation of the ATP-sensitive potassium channel. Ion Channels. 1990;2:205–222. doi: 10.1007/978-1-4615-7305-0_6. [DOI] [PubMed] [Google Scholar]