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. 1997 Jul;71(7):5620–5623. doi: 10.1128/jvi.71.7.5620-5623.1997

Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53.

J J Rushton 1, D Jiang 1, A Srinivasan 1, J M Pipas 1, P D Robbins 1
PMCID: PMC191805  PMID: 9188637

Abstract

A simian virus 40 (SV40) T-antigen mutant containing only the N-terminal 136 amino acids, able to bind to Rb and p300 but not p53, partially inhibited p53-mediated transcription without affecting the ability of p53 to bind DNA. These results suggest that SV40 T antigen can regulate p53-mediated transcription either directly through protein-protein association or indirectly through interaction with factors which may function to confer p53-mediated transcription.

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Selected References

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