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. 1991 Feb;102(2):369–372. doi: 10.1111/j.1476-5381.1991.tb12180.x

Secretion of growth hormone elicited by intravenous desipramine in the conscious, unrestrained rat.

M Grealy 1, J M O'Donnell 1
PMCID: PMC1918050  PMID: 1849767

Abstract

1. Acute intravenous administration of either clonidine (Clon) (50 micrograms kg-1) or desipramine (DMI) (5 mg kg-1) elicited a pulse of growth hormone (GH) and corticosterone secretion in conscious, unrestrained rats. 2. The responses to DMI were similar to those with Clon, except that the GH pulse following DMI was delayed and was not dose-dependent. 3. The GH response to DMI was inhibited by prior administration of idazoxan (1 mg kg-1) or yohimbine (0.5 mg kg-1), but not by atropine (10 micrograms kg-1), sulpiride (5 mg kg-1) or prazosin (1 mg kg-1). 4. The corticosterone secretion following DMI was not altered by prior atropine, sulpiride or prazosin, but was augmented by idazoxan (1 mg kg-1). 5. GH secretion was not influenced by atropine, sulpiride, prazosin or idazoxan given alone. Idazoxan or yohimbine given alone elicited significant secretion of corticosterone. 6. It is concluded that i.v. DMI caused an activation through indirect mechanisms of alpha 2-adrenoceptors specifically involved in hypothalamic-pituitary regulation of GH release and also a distinct, independent and transient generalized activation of the pituitary-adrenal axis.

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Selected References

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  1. Checkley S. A., Glass I. B., Thompson C., Corn T., Robinson P. The GH response to clonidine in endogenous as compared with reactive depression. Psychol Med. 1984 Nov;14(4):773–777. doi: 10.1017/s0033291700019747. [DOI] [PubMed] [Google Scholar]
  2. Durand D., Martin J. B., Brazeau P. Evidence for a role of alpha-adrenergic mechanisms in regulation of episodic growth hormone secretion in the rat. Endocrinology. 1977 Mar;100(3):722–728. doi: 10.1210/endo-100-3-722. [DOI] [PubMed] [Google Scholar]
  3. Edén S., Modigh K. Effects of apomorphine and clonidine on rat plasma growth hormone after pretreatment with reserpine and electroconvulsive shocks. Brain Res. 1977 Jul 1;129(2):379–384. doi: 10.1016/0006-8993(77)90020-8. [DOI] [PubMed] [Google Scholar]
  4. Eriksson E., Edén S., Modigh K. Up- and down- regulation of central postsynaptic alpha 2 receptors reflected in the growth hormone response to clonidine in reserpine-pretreated rats. Psychopharmacology (Berl) 1982;77(4):327–331. doi: 10.1007/BF00432764. [DOI] [PubMed] [Google Scholar]
  5. GLICK D., VONREDLICH D., LEVINE S. FLUOROMETRIC DETERMINATION OF CORTICOSTERONE AND CORTISOL IN 0.02-0.05 MILLILITERS OF PLASMA OR SUBMILLIGRAM SAMPLES OF ADRENAL TISSUE. Endocrinology. 1964 Apr;74:653–655. doi: 10.1210/endo-74-4-653. [DOI] [PubMed] [Google Scholar]
  6. Hall H., Ogren S. O. Effects of antidepressant drugs on different receptors in the brain. Eur J Pharmacol. 1981 Mar 26;70(3):393–407. doi: 10.1016/0014-2999(81)90172-2. [DOI] [PubMed] [Google Scholar]
  7. Harms P. G., Ojeda S. R. A rapid and simple procedure for chronic cannulation of the rat jugular vein. J Appl Physiol. 1974 Mar;36(3):391–392. doi: 10.1152/jappl.1974.36.3.391. [DOI] [PubMed] [Google Scholar]
  8. Krulich L., Mayfield M. A., Steele M. K., McMillen B. A., McCann S. M., Koenig J. I. Differential effects of pharmacological manipulations of central alpha 1- and alpha 2-adrenergic receptors on the secretion of thyrotropin and growth hormone in male rats. Endocrinology. 1982 Mar;110(3):796–804. doi: 10.1210/endo-110-3-796. [DOI] [PubMed] [Google Scholar]
  9. Laakmann G., Zygan K., Schoen H. W., Weiss A., Wittmann M., Meissner R., Blaschke D. Effect of receptor blockers (methysergide, propranolol, phentolamine, yohimbine and prazosin) on desimipramine-induced pituitary hormone stimulation in humans--I. Growth hormone. Psychoneuroendocrinology. 1986;11(4):447–461. doi: 10.1016/0306-4530(86)90006-5. [DOI] [PubMed] [Google Scholar]
  10. Müller E. E. Some aspects of the neurotransmitter control of anterior pituitary function. Pharmacol Res. 1989 Jan-Feb;21(1):75–85. doi: 10.1016/1043-6618(89)90125-4. [DOI] [PubMed] [Google Scholar]
  11. Rodbard D., Ruder H. J., Vaitukaitis J., Jacobs H. S. Mathematical analysis of kinetics of radioligand assays: improved sensitivity obtained by delayed addition of labeled ligand. J Clin Endocrinol Metab. 1971 Aug;33(2):343–355. doi: 10.1210/jcem-33-2-343. [DOI] [PubMed] [Google Scholar]
  12. Takahashi K., Daughaday W. H., Kipnis D. M. Regulation of immunoreactive growth hormone secretion in male rats. Endocrinology. 1971 Apr;88(4):909–917. doi: 10.1210/endo-88-4-909. [DOI] [PubMed] [Google Scholar]
  13. Tannenbaum G. S., Martin J. B. Evidence for an endogenous ultradian rhythm governing growth hormone secretion in the rat. Endocrinology. 1976 Mar;98(3):562–570. doi: 10.1210/endo-98-3-562. [DOI] [PubMed] [Google Scholar]
  14. Terry L. C., Willoughby J. O., Braseau P., Martin J. B., Patel Y. Antiserum to somatostatin prevents stress-induced inhibition of growth hormone secretion in the rat. Science. 1976 May 7;192(4239):565–567. doi: 10.1126/science.1257793. [DOI] [PubMed] [Google Scholar]

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