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. 1997 Aug;71(8):5764–5768. doi: 10.1128/jvi.71.8.5764-5768.1997

Functional management of an antiviral cytotoxic T-cell response.

M F Bachmann 1, D E Speiser 1, P S Ohashi 1
PMCID: PMC191829  PMID: 9223463

Abstract

Lymphocytic choriomeningitis virus (LCMV) is known to induce strong, polyclonal cytotoxic T-lymphocyte (CTL) responses. Using a set of variant peptides derived from the major CTL epitope of LCMV, we analyzed the functional fine specificity of the LCMV-specific CTL response. During the primary response, almost all the tested peptides were recognized. In contrast, the secondary response was purged of all minor cross-reactivities and very few peptides were significantly recognized. This study is the first demonstration of the functional maturation of a T-cell response and has important clinical and biological implications.

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Selected References

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