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. 1994 Nov;55(5):870–875.

Familial Site-specific Ovarian Cancer Is Linked to BRCA1 on 17q12-21

Elisabeth Steichen-Gersdorf, Holly H Gallion, Deborah Ford, Catherine Girodet, Douglas F Easton, Richard A DiCioccio, Gareth Evans, Margaret A Ponder, Carole Pye, Sylvie Mazoyer, Tetsuro Noguchi, Fabienne Karengueven, Hagay Sobol, A Hardouin, Yves-Jean Bignon, M Steven Piver, Simon A Smith, Bruce A J Ponder
PMCID: PMC1918337  PMID: 7977348

Abstract

In a study of nine families with “site-specific” ovarian cancer (criterion: three or more cases of epithelial ovarian cancer and no cases of breast cancer diagnosed at age <50 years) we have obtained evidence of linkage to the breast-ovarian cancer susceptibility gene, BRCA1 on 17q12-21. If the risk of cancer in these families is assumed to be restricted to the ovary, the best estimate of the proportion of families linked to BRCA1 is .78 (95% confidence interval .32–1.0). If predisposition to both breast and ovarian cancer is assumed, the proportion linked is 1.0 (95% confidence interval .46–1.0). The linkage of familial site-specific ovarian cancer to BRCA1 indicates the possibility of predictive testing in such families; however, this is only appropriate in families where the evidence for linkage to BRCA1 is conclusive.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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