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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1994 Aug;55(2):334–340.

Translocation involving 1p and 17q is a recurrent genetic alteration of human neuroblastoma cells.

L Savelyeva 1, R Corvi 1, M Schwab 1
PMCID: PMC1918368  PMID: 8037210

Abstract

Human neuroblastoma cells often are monosomic for the distal portion of 1p (1p36). We report that the deleted 1p material in cells of neuroblastoma lines is preferentially replaced by material from chromosome 17, resulting from an unbalanced 1;17 translocation. Chromosome 17 often acquires instability, followed by the integration of fragments into various marker chromosomes. As a consequence, 17q material can increase over 17p material. The nonrandom frequency of 1;17 translocations appears to indicate an as-yet-undefined contribution to neuroblastoma development.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Gilbert F., Feder M., Balaban G., Brangman D., Lurie D. K., Podolsky R., Rinaldt V., Vinikoor N., Weisband J. Human neuroblastomas and abnormalities of chromosomes 1 and 17. Cancer Res. 1984 Nov;44(11):5444–5449. [PubMed] [Google Scholar]
  2. Hayashi Y., Kanda N., Inaba T., Hanada R., Nagahara N., Muchi H., Yamamoto K. Cytogenetic findings and prognosis in neuroblastoma with emphasis on marker chromosome 1. Cancer. 1989 Jan 1;63(1):126–132. doi: 10.1002/1097-0142(19890101)63:1<126::aid-cncr2820630120>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  3. Hunt J. D., Tereba A. Molecular evaluation of abnormalities of the short arm of chromosome 1 in neuroblastoma. Genes Chromosomes Cancer. 1990 Jul;2(2):137–146. doi: 10.1002/gcc.2870020210. [DOI] [PubMed] [Google Scholar]
  4. Laureys G., Speleman F., Opdenakker G., Benoit Y., Leroy J. Constitutional translocation t(1;17)(p36;q12-21) in a patient with neuroblastoma. Genes Chromosomes Cancer. 1990 Sep;2(3):252–254. doi: 10.1002/gcc.2870020315. [DOI] [PubMed] [Google Scholar]
  5. Martinsson T., Weith A., Cziepluch C., Schwab M. Chromosome 1 deletions in human neuroblastomas: generation and fine mapping of microclones from the distal 1p region. Genes Chromosomes Cancer. 1989 Sep;1(1):67–78. doi: 10.1002/gcc.2870010111. [DOI] [PubMed] [Google Scholar]
  6. Ohgaki H., Eibl R. H., Schwab M., Reichel M. B., Mariani L., Gehring M., Petersen I., Höll T., Wiestler O. D., Kleihues P. Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system. Mol Carcinog. 1993;8(2):74–80. doi: 10.1002/mc.2940080203. [DOI] [PubMed] [Google Scholar]
  7. Pietsch T., Göttert E., Meese E., Blin N., Feickert H. J., Riehm H., Kovacs G. Characterization of a continuous cell line (MHH-NB-11) derived from advanced neuroblastoma. Anticancer Res. 1988 Nov-Dec;8(6):1329–1333. [PubMed] [Google Scholar]
  8. Ritke M. K., Shah R., Valentine M., Douglass E. C., Tereba A. Molecular analysis of chromosome 1 abnormalities in neuroblastoma. Cytogenet Cell Genet. 1989;50(2-3):84–90. doi: 10.1159/000132729. [DOI] [PubMed] [Google Scholar]
  9. Ross R. A., Spengler B. A., Biedler J. L. Coordinate morphological and biochemical interconversion of human neuroblastoma cells. J Natl Cancer Inst. 1983 Oct;71(4):741–747. [PubMed] [Google Scholar]
  10. Seeger R. C., Danon Y. L., Rayner S. A., Hoover F. Definition of a Thy-1 determinant on human neuroblastoma, glioma, sarcoma, and teratoma cells with a monoclonal antibody. J Immunol. 1982 Feb;128(2):983–989. [PubMed] [Google Scholar]
  11. Seeger R. C., Rayner S. A., Banerjee A., Chung H., Laug W. E., Neustein H. B., Benedict W. F. Morphology, growth, chromosomal pattern and fibrinolytic activity of two new human neuroblastoma cell lines. Cancer Res. 1977 May;37(5):1364–1371. [PubMed] [Google Scholar]
  12. Shapiro D. N., Valentine M. B., Rowe S. T., Sinclair A. E., Sublett J. E., Roberts W. M., Look A. T. Detection of N-myc gene amplification by fluorescence in situ hybridization. Diagnostic utility for neuroblastoma. Am J Pathol. 1993 May;142(5):1339–1346. [PMC free article] [PubMed] [Google Scholar]
  13. Takayama H., Suzuki T., Mugishima H., Fujisawa T., Ookuni M., Schwab M., Gehring M., Nakamura Y., Sugimura T., Terada M. Deletion mapping of chromosomes 14q and 1p in human neuroblastoma. Oncogene. 1992 Jun;7(6):1185–1189. [PubMed] [Google Scholar]
  14. Takeda O., Homma C., Maseki N., Sakurai M., Kanda N., Schwab M., Nakamura Y., Kaneko Y. There may be two tumor suppressor genes on chromosome arm 1p closely associated with biologically distinct subtypes of neuroblastoma. Genes Chromosomes Cancer. 1994 May;10(1):30–39. doi: 10.1002/gcc.2870100106. [DOI] [PubMed] [Google Scholar]
  15. Tumilowicz J. J., Nichols W. W., Cholon J. J., Greene A. E. Definition of a continuous human cell line derived from neuroblastoma. Cancer Res. 1970 Aug;30(8):2110–2118. [PubMed] [Google Scholar]
  16. Vogan K., Bernstein M., Leclerc J. M., Brisson L., Brossard J., Brodeur G. M., Pelletier J., Gros P. Absence of p53 gene mutations in primary neuroblastomas. Cancer Res. 1993 Nov 1;53(21):5269–5273. [PubMed] [Google Scholar]
  17. Wada R. K., Seeger R. C., Brodeur G. M., Slamon D. J., Rayner S. A., Tomayko M., Reynolds C. P. Characterization of human neuroblastoma cell lines that lack N-myc gene amplification. Prog Clin Biol Res. 1988;271:57–69. [PubMed] [Google Scholar]
  18. Weith A., Martinsson T., Cziepluch C., Brüderlein S., Amler L. C., Berthold F., Schwab M. Neuroblastoma consensus deletion maps to 1p36.1-2. Genes Chromosomes Cancer. 1989 Nov;1(2):159–166. doi: 10.1002/gcc.2870010209. [DOI] [PubMed] [Google Scholar]

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