Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1992 Aug;36(8):1682–1687. doi: 10.1128/aac.36.8.1682

Antibiotic susceptibility survey of Neisseria gonorrhoeae in Thailand.

T E Clendennen 1, P Echeverria 1, S Saengeur 1, E S Kees 1, J W Boslego 1, F S Wignall 1
PMCID: PMC192030  PMID: 1416851

Abstract

The antibiotic susceptibilities of Neisseria gonorrhoeae isolates obtained from patients attending sexually transmitted disease clinics in Cholburi and Bangkok, Thailand, were determined by agar dilution. Some 28.2% of isolates produced beta-lactamase. A total of 97.9% of beta-lactamase-positive and 51% of beta-lactamase-negative isolates tested were resistant to penicillin (MICs, greater than or equal to 2 micrograms/ml), 70% of isolates tested were resistant to tetracycline (MICs, greater than or equal to 2 micrograms/ml), and 91% of isolates tested were susceptible to spectinomycin (MICs, less than or equal to 64 micrograms/ml). The MICs for 90% of isolates for the other drugs tested were 2 micrograms/ml for erythromycin, 2 micrograms/ml for cefoxitin, 1 micrograms/ml for cefuroxime, 0.125 micrograms/ml for cefpodoxime, 0.06 micrograms/ml for cefotaxime, 0.25 micrograms/ml for ceftazidime, 0.03 micrograms/ml for ceftizoxime, 0.03 micrograms/ml for ceftriaxone, 0.03 micrograms/ml for cefixime, 0.06 micrograms/ml for aztreonam, 0.008 micrograms/ml for ciprofloxacin, 0.125 micrograms/ml for norfloxacin, and 0.075 micrograms/ml for ofloxacin. Fewer than 1.5% of isolates were resistant to the extended-spectrum cephalosporins tested. Some 0.3% or fewer isolates were resistant to broad-spectrum cephalosporins, fluoroquinolones, or the monobactam aztreonam. Antibiotic resistance among N. gonorrhoeae isolates from Cholburi and Bangkok in May 1990 appeared to be primarily limited to penicillin and tetracycline, which are no longer used to control gonorrhea. Spectinomycin, which has been in general use against gonorrhea in Thailand since 1983, has dwindling utility, with resistance at a level of 8.9%.

Full text

PDF
1682

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berliner D. S., No P. U. Prevalence of penicillinase-producing Neisseria gonorrheae in Korea. Aviat Space Environ Med. 1986 Dec;57(12 Pt 1):1170–1175. [PubMed] [Google Scholar]
  2. Brown S., Warnnissorn T., Biddle J., Panikabutra K., Traisupa A. Antimicrobial resistance of Neisseria gonorrhoea in Bangkok: is single-drug treatment passé. Lancet. 1982 Dec 18;2(8312):1366–1368. doi: 10.1016/s0140-6736(82)91271-5. [DOI] [PubMed] [Google Scholar]
  3. Harrison W. O., Wignall F. S., Kerbs S. B., Berg S. W. Oral rosoxacin for treatment of penicillin-resistant gonorrhoea. Lancet. 1984 Mar 10;1(8376):566–566. doi: 10.1016/s0140-6736(84)90962-0. [DOI] [PubMed] [Google Scholar]
  4. Jones R. N., Gavan T. L., Thornsberry C., Fuchs P. C., Gerlach E. H., Knapp J. S., Murray P., Washington J. A., 2nd Standardization of disk diffusion and agar dilution susceptibility tests for Neisseria gonorrhoeae: interpretive criteria and quality control guidelines for ceftriaxone, penicillin, spectinomycin, and tetracycline. J Clin Microbiol. 1989 Dec;27(12):2758–2766. doi: 10.1128/jcm.27.12.2758-2766.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Jones R. N., Gerlach E. H., Koontz F. P., Murray P. R., Pfaller M. A., Washington J. A., Erwin M. E., Knapp C. C. Interpretive criteria and quality control guidelines for Neisseria gonorrhoeae susceptibility test standardization for cefotetan. J Clin Microbiol. 1991 Feb;29(2):363–366. doi: 10.1128/jcm.29.2.363-366.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Knapp J. S. Laboratory methods for the detection and phenotypic characterization of Neisseria gonorrhoeae strains resistant to antimicrobial agents. Sex Transm Dis. 1988 Oct-Dec;15(4):225–233. doi: 10.1097/00007435-198810000-00009. [DOI] [PubMed] [Google Scholar]
  7. Piziak M. V., Woodbury C., Berliner D., Takafuji E., Kirkpatrick J., Opal S., Tramont E. Resistance trends of Neisseria gonorrhoeae in the Republic of Korea. Antimicrob Agents Chemother. 1984 Jan;25(1):7–9. doi: 10.1128/aac.25.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Schwarcz S. K., Zenilman J. M., Schnell D., Knapp J. S., Hook E. W., 3rd, Thompson S., Judson F. N., Holmes K. K. National surveillance of antimicrobial resistance in Neisseria gonorrhoeae. The Gonococcal Isolate Surveillance Project. JAMA. 1990 Sep 19;264(11):1413–1417. [PubMed] [Google Scholar]
  9. Slack R. Antibiotic resistance in the tropics. 2. Some thoughts on the epidemiology and clinical significance of bacterial resistance to antimicrobial agents. Trans R Soc Trop Med Hyg. 1989 Jan-Feb;83(1):42–44. doi: 10.1016/0035-9203(89)90701-3. [DOI] [PubMed] [Google Scholar]
  10. Traisupa A., Ariyarit C., Saengsur S., Theeratum C., Tharavanich S. Spectinomycin-resistant gonococci in Thailand. Clin Ther. 1990 Mar-Apr;12(2):101–104. [PubMed] [Google Scholar]
  11. Turner A., Jephcott A. E., Gough K. R. Laboratory detection of ciprofloxacin resistant Neisseria gonorrhoeae. J Clin Pathol. 1991 Feb;44(2):169–170. doi: 10.1136/jcp.44.2.169. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES