Abstract
The intensity of experimental and clinical immune responses was correlated with the degree of glycemia of the reacting subject. Hyperglycemias resulting from overdosage with sugars, cortisol, adrenaline, or from diabetes inhibit the anaphylactoid reactions; anaphylaxis, and the tuberculin reaction; but potentiate infections. Hypoglycemias resulting from fasting, insulin and adrenalectomy potentiate the anaphylactoid reactions, anaphylaxis, and the tuberculin reaction; but inhibit infections. The hypothesis is proposed that hyperglycemia inhibits certain antigen-antibody combinations; this results in an inhibition of hypersensitivity, but an aggravation of infection.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ADAMKIEWICZ V. W., ADAMKIEWICZ L. M. Alloxan diabetes and dextran anaphylactoid inflammation. Am J Physiol. 1959 Aug;197:377–379. doi: 10.1152/ajplegacy.1959.197.2.377. [DOI] [PubMed] [Google Scholar]
- ADAMKIEWICZ V. W., FITKO R. J., FORTIER A. A. Hypoglycemic drugs and the dextran 'anaphylactoid' inflammation. Can J Biochem Physiol. 1960 Aug;38:823–827. [PubMed] [Google Scholar]
- ADAMKIEWICZ V. W., LANGLOIS Y. L., POIRIER L. J. Sensitization by insulin to dextran anaphylactoid inflammation in spinal rats. Am J Physiol. 1958 Dec;195(3):635–638. doi: 10.1152/ajplegacy.1958.195.3.635. [DOI] [PubMed] [Google Scholar]
- ADAMKIEWICZ V. W., LANGLOIS Y. Sensitization by insulin to the dextran anaphylactoid reaction. Can J Biochem Physiol. 1957 Apr;35(4):251–256. [PubMed] [Google Scholar]
- GANLEY O. H. Studies on the prevention of sensitization by Bordetella pertussis in alloxan diabetic mice. Can J Biochem Physiol. 1962 Sep;40:1179–1183. [PubMed] [Google Scholar]
- GOTH A. Inhibition of anaphylactoid edema in the rat by 2-deoxyglucose. Am J Physiol. 1959 Nov;197:1056–1058. doi: 10.1152/ajplegacy.1959.197.5.1056. [DOI] [PubMed] [Google Scholar]
- GOTH A., NASH W. L., NAGLER M., HOLMAN J. Inhibition of histamine release in experimental diabetes. Am J Physiol. 1957 Oct;191(1):25–28. doi: 10.1152/ajplegacy.1957.191.1.25. [DOI] [PubMed] [Google Scholar]
- LONG D. A. The influence of nutritional and hormonal factors upon immune and allergic responses to infection. Can Med Assoc J. 1956 May 15;74(10):771–782. [PMC free article] [PubMed] [Google Scholar]
- MOLLERSTROM J., SOLLBERGER A. Fundamental concepts underlying the metabolic periodicity in diabetes. Ann N Y Acad Sci. 1962 Oct 30;98:984–994. doi: 10.1111/j.1749-6632.1962.tb30613.x. [DOI] [PubMed] [Google Scholar]
- SANYAL R. K., SPENCER P. S., WEST G. B. Insulin and hypersensitivity. Nature. 1959 Dec 26;184(Suppl 26):2020–2020. doi: 10.1038/1842020a0. [DOI] [PubMed] [Google Scholar]
- THOMPSON G. E. Alloxan and hypersensitivity. Nature. 1961 May 27;190:822–822. doi: 10.1038/190822a0. [DOI] [PubMed] [Google Scholar]
- TOOLAN H. W. Subcutaneous growth of normal and malignant human tissues in heterologous hosts. Trans N Y Acad Sci. 1955 Jun;17(8):589–593. doi: 10.1111/j.2164-0947.1955.tb03494.x. [DOI] [PubMed] [Google Scholar]