Abstract
Ethamivan was used as a respiratory analeptic in the treatment of nine cases of severe barbiturate poisoning. Initial intravenous injections of 100 to 150 mg. of ethamivan increased the depth of respirations within a minute. Prolonged respiratory stimulation was achieved by a continuous intravenous infusion of 500 to 3000 mg. of ethamivan per litre of fluid. If hypotension occurred, an intravenous drip of noradrenaline was used; fluid overloading was avoided by adjusting the concentrations of drugs given, so that no more than a total of 125 c.c. of fluid per hour was administered. The chief side effect of overdosage of ethamivan was muscular twitching. This did not prove to be a problem and was of some value in determining the amount of drug given. The nine patients survived. It was concluded that ethamivan is a useful agent in the treatment of barbiturate poisoning.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ADRIANI J., DRAKE P., ARENS J. Use of antagonists in drug-induced coma. JAMA. 1962 Mar 10;179:752–758. doi: 10.1001/jama.1962.03050100006002. [DOI] [PubMed] [Google Scholar]
- ARONOVITCH M., KAHANA L. M., MEAKINS J. F., PLACE R. E., LAING R. Vanillic diethylamide in the management of acute respiratory insufficiency: a preliminary report. Can Med Assoc J. 1961 Oct 14;85:875–885. [PMC free article] [PubMed] [Google Scholar]
- MILLER M. J., HAND B. M., CRELLIN J. A. Pharmacologic effects of intravenous vanillic acid diethylamide in man. Clin Pharmacol Ther. 1961 Sep-Oct;2:689–691. doi: 10.1002/cpt196125689. [DOI] [PubMed] [Google Scholar]
- ROMAGNOLI A., DIAMOND M. J. Some trails with vanillic diethylamide: a new analeptic. Can Anaesth Soc J. 1961 Nov;8:551–555. doi: 10.1007/BF03021387. [DOI] [PubMed] [Google Scholar]