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. 1963 Nov 2;89(18):917–920.

Peripheral Neuropathy Following Chloroquine Therapy

Lawrence R Loftus
PMCID: PMC1921850  PMID: 14052974

Abstract

Four patients were observed who developed similar episodes of peripheral neuropathy following prolonged treatment with chloroquine phosphate. This previously unreported toxic reaction consisted of bilateral loss of knee and ankle reflexes and weakness of the quadriceps muscles. Gradual return to normal followed withdrawal of the chloroquine. Other toxic reactions to the drug are reviewed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BAGNALL A. W. The value of chloroquine in rheumatoid disease: a four-year study of continuous therapy. Can Med Assoc J. 1957 Aug 1;77(3):182–194. [PMC free article] [PubMed] [Google Scholar]
  2. HOBBS H. E., CALNAN C. D. The ocular complications of chloroquine therapy. Lancet. 1958 Jun 7;1(7032):1207–1209. doi: 10.1016/s0140-6736(58)91911-1. [DOI] [PubMed] [Google Scholar]
  3. HOBBS H. E., SORSBY A., FREEDMAN A. Retinopathy following chloroquine therapy. Lancet. 1959 Oct 3;2(7101):478–480. doi: 10.1016/s0140-6736(59)90604-x. [DOI] [PubMed] [Google Scholar]
  4. Hobbs H. E., Eadie S. P., Somerville F. OCULAR LESIONS AFTER TREATMENT WITH CHLOROQUINE. Br J Ophthalmol. 1961 Apr;45(4):284–297. doi: 10.1136/bjo.45.4.284. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. KALSBEEK F. [Bilateral paralysis of the abducent nerve as cause of diplopia after the use of chloroquine]. Ned Tijdschr Geneeskd. 1960 Jul 23;104:1414–1416. [PubMed] [Google Scholar]
  6. LOFTUS L. R., WAGNER A. W. New allergic reaction to furaltadone. J Am Med Assoc. 1960 May 28;173:362–363. doi: 10.1001/jama.1960.73020220008008b. [DOI] [PubMed] [Google Scholar]
  7. PAGE F. Treatment of lupus erythematosus with mepacrine. Lancet. 1951 Oct 27;2(6687):755–758. doi: 10.1016/s0140-6736(51)91643-1. [DOI] [PubMed] [Google Scholar]
  8. PENNER R., SOMERS K. Bilateral macular degeneration associated with chloroquine therapy. Am J Ophthalmol. 1962 Sep;54:381–385. doi: 10.1016/0002-9394(62)93754-6. [DOI] [PubMed] [Google Scholar]
  9. REED H., CAMPBELL A. A. Central scotomata following chloroquine therapy. Can Med Assoc J. 1962 Jan 27;86:176–178. [PMC free article] [PubMed] [Google Scholar]
  10. ZELLER R. W., DEERING D. Corneal complication of chloroquine (aralen) phosphate therapy. J Am Med Assoc. 1958 Dec 27;168(17):2263–2264. doi: 10.1001/jama.1958.63000170007012b. [DOI] [PubMed] [Google Scholar]

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