Abstract
The ovaries from 75 females ranging in age from the newborn to 96 years were subjected to histologic scrutiny. Ageing phenomena comprising the gonad's life-long metamorphosis were documented. The cause of menopausal ovarian failure is twofold: (1) Ovarian vessel wall thickening and hyalinization as the cardiovascular system ages reduces perfusion of the gonad. (The blood supply of the ovaries is well designed to permit mobility but longevity of function is sacrificed.) (2) Gradual replacement of egg- and hormone-producing cells by fibrous tissue. This scar tissue accumulates as a result of ovulation and pregnancy and is less efficiently removed from the ovary in the later fertile years. By inhibiting ovulation, the oral contraceptives will likely delay the natural senescence of the ovary. More basic research is indicated to elucidate the mechanism of oogenesis.
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