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. 1963 Oct 19;89(16):806–809.

Clinical Studies of Neuropathy due to Macroglobulinemia (Waldenström's Syndrome)

James E Gotham, Howard Wein, John S Meyer
PMCID: PMC1922069  PMID: 14060173

Abstract

A case of severe neuropathy due to macro-globulinemia is reported with clinical, biochemical and electrophysiological studies. The clinical picture was that of a severe, symmetrical polyneuropathy of a sensory-motor type with increased protein in the CSF. Sedimentation rate was increased and a sharp rise was found in the globulin fractions on plasma electrophoresis. Immuno-assays of CSF showed increases of albumin, transferrin and gamma globulin. Blood chromosome studies were normal. EMG showed neuromuscular atrophy. Nerve conduction times were prolonged. These studies are compatible with a neuropathy of an allergic or metabolic nature. Macro-globulinemia of Waldenström should be considered in the differential diagnosis of obscure neuropathies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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