Abstract
Since the inoculation of newborn hamsters with polyoma virus results both in necrotizing lesions and virus-free tumours the possibility was raised that necrotizing viruses found in man acted similarly. Accordingly a group of viruses found in man were tested for oncogenic activity by injecting them into newborn hamsters. Most were observed for more than a year. As yet only Adenovirus Types 12 and 18 have induced tumours; the oncogenic properties of these were reported by Trentin et al., and Huebner et al., respectively, while this study was in progress. The significance of the findings with regard to man cannot as yet be evaluated but the point is made that Adenovirus Types 12 and 18, like polyoma and SV40 virus, only cause neoplasia under special circumstances. Further work will be required to discover if these circumstances or their equivalent occur under conditions of the natural spread of infection.
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- AXELRAD A. A., VAN DER GAAG H. C. Susceptibility of lymphoma induction by gross' passage A virus in C3Hf/Bi mice of different ages: relation to thymic cell multiplication and differentiation. J Natl Cancer Inst. 1962 May;28:1065–1093. [PubMed] [Google Scholar]
- DAWE C. J., LAW L. W., DUNN T. B. Studies of parotid-tumor agent in cultures of leukemic tissues of mice. J Natl Cancer Inst. 1959 Oct;23:717–797. [PubMed] [Google Scholar]
- Ditchfield J., Macpherson L. W., Zbitnew A. Association of Canine Adenovirus (Toronto A 26/61) with an Outbreak of Laryngotracheitis ("Kennel Cough"): A Preliminary Report. Can Vet J. 1962 Aug;3(8):238–247. [PMC free article] [PubMed] [Google Scholar]
- EDDY B. E., BORMAN G. S., BERKELEY W. H., YOUNG R. D. Tumors induced in hamsters by injection of rhesus monkey kidney cell extracts. Proc Soc Exp Biol Med. 1961 May;107:191–197. doi: 10.3181/00379727-107-26576. [DOI] [PubMed] [Google Scholar]
- GIRARDI A. J., SWEET B. H., SLOTNICK V. B., HILLEMAN M. R. Development of tumors in hamsters inoculated in the neonatal period with vacuolating virus, SV-40. Proc Soc Exp Biol Med. 1962 Mar;109:649–660. doi: 10.3181/00379727-109-27298. [DOI] [PubMed] [Google Scholar]
- HUEBNER R. J., ROWE W. P., LANE W. T. Oncogenic effects in hamsters of human adenovirus types 12 and 18. Proc Natl Acad Sci U S A. 1962 Dec 15;48:2051–2058. doi: 10.1073/pnas.48.12.2051. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TRENTIN J. J., YABE Y., TAYLOR G. The quest for human cancer viruses. Science. 1962 Sep 14;137(3533):835–841. doi: 10.1126/science.137.3533.835. [DOI] [PubMed] [Google Scholar]