Abstract
Toxic dilatation of the colon is now a well-recognized complication of ulcerative colitis. Our experience with four cases is presented. The clinical picture was characterized by severe ulcerative colitis with increasing abdominal distension, high swinging temperatures, obvious toxicity, and a moderate to high leukocytosis with a pronounced shift to younger forms. Accurate history and physical examination, plain radiographs of the abdomen, sigmoidoscopy and, most important of all, awareness of the condition facilitate diagnosis in most cases. The main indications for surgical intervention are progressive abdominal distension and impending or actual perforation. Ileostomy and subtotal or total colectomy are the surgical procedures of choice. We feel that steroids play little part in the early management, but are of value in the early postoperative period. The three patients in our series treated surgically survived. One treated by medical means alone died of peritonitis.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- BEBCHUK W., ROGERS A. G., DOWNEY J. L. Chronic ulcerative colitis in a North American Indian. Gastroenterology. 1961 Jan;40:138–140. [PubMed] [Google Scholar]
- COHN E. M., COPIT P., TUMEN H. J. Ulcerative colitis with hypopotassemia. Gastroenterology. 1956 Jun;30(6):950–957. [PubMed] [Google Scholar]
- GOLDGRABER M. B., KIRSNER J. B., PALMER W. L. The role of ACTH and adrenal steroids in perforation of the colon in ulcerative colitis; a clinical-pathologic study. Gastroenterology. 1957 Sep;33(3):434–456. [PubMed] [Google Scholar]
- LENNARD-JONES J. E., VIVIAN A. B. Fulminating ulcerative colitis. Recent experience in management. Br Med J. 1960 Jul 9;2(5192):96–102. doi: 10.1136/bmj.2.5192.96. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MADISON M. S., BARGEN J. A. Fulminating chronic ulcerative colitis with unusual segmental dilatation of the colon; report of case. Proc Staff Meet Mayo Clin. 1951 Jan 3;26(1):21–24. [PubMed] [Google Scholar]
- McCONNELL F., HANELIN J., ROBBINS L. L. Plain film diagnosis of fulminating ulcerative colitis. Radiology. 1958 Nov;71(5):674–682. doi: 10.1148/71.5.674. [DOI] [PubMed] [Google Scholar]
- RANKIN J. G., GOULSTON S. J., BONEN R. W., MORROW A. W. Fulminant ulcerative colitis. Q J Med. 1960 Jul;29:375–390. [PubMed] [Google Scholar]
- TRUELOVE S. C., WITTS L. J. Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J. 1955 Oct 29;2(4947):1041–1048. doi: 10.1136/bmj.2.4947.1041. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WARREN S., SOMMERS S. C. Pathogenesis of ulcerative colitis. Am J Pathol. 1949 Jul;25(4):657–679. [PMC free article] [PubMed] [Google Scholar]
- WILLIAMS C. L., ROBINSON D. W. Toxic megacolon syndrome of ulcerative colitis. Ann Surg. 1962 Feb;155:233–237. doi: 10.1097/00000658-196200000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]