Abstract
Case reports of three residents of Ontario with clinical histoplasmic chorioretinitis are presented. The diagnosis was made on the basis of the clinical appearance, the presence of calcified lesions in the chest, a negative skin test to tuberculin, and a positive skin test to toxoplasmin. All patients were treated with intravenous amphotericin B. Except for transitory elevation of blood urea nitrogen, there were no serious complications from the drug and in all cases the lesions in the eyes were improved. Histologic or cultural proof of the presence of fungus in the eye is not available, but clinical and laboratory findings can combine to point to the diagnosis of histoplasmosis. In such cases, since vision is at stake, treatment with amphotericin B should be considered.
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- Christie A., Peterson J. C. Pulmonary Calcification in Negative Reactors to Tuberculin. Am J Public Health Nations Health. 1945 Nov;35(11):1131–1147. doi: 10.2105/ajph.35.11.1131. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FURCOLOW M. L., MENGES R. W. Comparison of histoplasmin sensitivity rates among human beings and animals in Boone County, Missouri. Am J Public Health Nations Health. 1952 Aug;42(8):926–929. doi: 10.2105/ajph.42.8.926. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FURCOLOW M. L., SCHWARZ J., HEWELL B. A., GRAYSTON J. T. Incidence of tuberculin, histoplasmin, and blastomycin reactors among a group of school children. Am J Public Health Nations Health. 1953 Dec;43(12):1523–1531. doi: 10.2105/ajph.43.12.1523. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Falls H. F., Giles C. L. The Use of Amphotericin B in Selected Cases of Chorioretinitis. Trans Am Ophthalmol Soc. 1959;57:344–363. [PMC free article] [PubMed] [Google Scholar]
- Fischer J. B., Barnum D. A. Mycotic Infections Common to Man and Animals. Can Med Assoc J. 1960 Mar 26;82(13):689–693. [PMC free article] [PubMed] [Google Scholar]
- GRAYSTON J. T., LOOSLI C. G., ALEXANDER E. R. The isolation of Histoplasma capsulatum from soil in an unused silo. Science. 1951 Sep 28;114(2961):323–324. doi: 10.1126/science.114.2961.323. [DOI] [PubMed] [Google Scholar]
- HAGGAR R. A., BROWN E. L., TOPLACK N. J. Histoplasmosis in southwestern Ontario. Can Med Assoc J. 1957 Nov 1;77(9):855–861. [PMC free article] [PubMed] [Google Scholar]
- HEATON T. G., BROWN M. H. Intradermal histoplasmin reactors at the University of Toronto. Can Med Assoc J. 1955 Apr 1;72(7):531–531. [PMC free article] [PubMed] [Google Scholar]
- LEHAN P. H., FURCOLOW M. L. Epidemic histoplasmosis. J Chronic Dis. 1957 Apr;5(4):489–503. doi: 10.1016/0021-9681(57)90117-0. [DOI] [PubMed] [Google Scholar]
- LOOSLI C. G. Histoplasmosis. J Chronic Dis. 1957 Apr;5(4):473–488. doi: 10.1016/0021-9681(57)90116-9. [DOI] [PubMed] [Google Scholar]
- MANKIEWICZ E., BLANK F., RUBIN J. H. Pulmonary histoplasmosis with cavitation. Can Med Assoc J. 1954 Oct;71(4):386–387. [PMC free article] [PubMed] [Google Scholar]
- MOCHI A., EDWARDS P. Q. Geographical distribution of histoplasmosis and histoplasmin sensitivity. Bull World Health Organ. 1952;5(3):259–291. [PMC free article] [PubMed] [Google Scholar]
- WALKER W. J., JANES E. C. Pulmonary histoplasmosis. Can Med Assoc J. 1959 Sep 15;81:486–488. [PMC free article] [PubMed] [Google Scholar]
- Woods A. C., Wahlen H. E. The Probable Role of Benign Histoplasmosis in the Etiology of Granulomatous Uveitis. Trans Am Ophthalmol Soc. 1959;57:318–343. [PMC free article] [PubMed] [Google Scholar]
- ZEIDBERG L. D., AJELLO L., DILLON A., RUNYON L. C. Isolation of histoplasma capsulatum from soil. Am J Public Health Nations Health. 1952 Aug;42(8):930–935. doi: 10.2105/ajph.42.8.930. [DOI] [PMC free article] [PubMed] [Google Scholar]