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. 1993 Oct;37(10):2228–2230. doi: 10.1128/aac.37.10.2228

Augmentation of murine tumor necrosis factor production by amphotericin B in vitro and in vivo.

Y Tokuda 1, M Tsuji 1, M Yamazaki 1, S Kimura 1, S Abe 1, H Yamaguchi 1
PMCID: PMC192255  PMID: 8257149

Abstract

Murine peritoneal macrophages were preincubated with amphotericin B (AMPH) and were then stimulated with bacterial lipopolysaccharide or streptococcal preparation (OK432). These macrophages produced a large amount of tumor necrosis factor. When administered to mice, the priming activity of amphotericin B for tumor necrosis factor production in vivo was also observed.

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Selected References

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  1. Beutler B., Milsark I. W., Cerami A. C. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science. 1985 Aug 30;229(4716):869–871. doi: 10.1126/science.3895437. [DOI] [PubMed] [Google Scholar]
  2. Chia J. K., McManus E. J. In vitro tumor necrosis factor induction assay for analysis of febrile toxicity associated with amphotericin B preparations. Antimicrob Agents Chemother. 1990 May;34(5):906–908. doi: 10.1128/aac.34.5.906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chia J. K., Pollack M. Amphotericin B induces tumor necrosis factor production by murine macrophages. J Infect Dis. 1989 Jan;159(1):113–116. doi: 10.1093/infdis/159.1.113. [DOI] [PubMed] [Google Scholar]
  4. Djeu J. Y., Blanchard D. K., Halkias D., Friedman H. Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: activation by interferon-gamma and tumor necrosis factor. J Immunol. 1986 Nov 1;137(9):2980–2984. [PubMed] [Google Scholar]
  5. Djeu J. Y., Serbousek D., Blanchard D. K. Release of tumor necrosis factor by human polymorphonuclear leukocytes. Blood. 1990 Oct 1;76(7):1405–1409. [PubMed] [Google Scholar]
  6. Okutomi T., Nakajima Y., Sakakibara F., Kawauchi H., Yamazaki M. Induction of release of cytotoxin from murine bone marrow cells by an animal lectin. Cancer Res. 1987 Jan 1;47(1):47–50. [PubMed] [Google Scholar]
  7. Okutomi T., Satoh M., Oshima H., Yamazaki M. Antigens associated with various cytotoxic activities of murine peripheral macrophages. Microbiol Immunol. 1986;30(10):1037–1047. doi: 10.1111/j.1348-0421.1986.tb03033.x. [DOI] [PubMed] [Google Scholar]
  8. Perfect J. R., Granger D. L., Durack D. T. Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. J Infect Dis. 1987 Aug;156(2):316–323. doi: 10.1093/infdis/156.2.316. [DOI] [PubMed] [Google Scholar]
  9. Satoh M., Oshima H., Abe S., Yamazaki M., Mizuno D. Role of in vivo scavenger function of macrophages in priming for endogenous production of tumor necrosis factor. J Biol Response Mod. 1987 Oct;6(5):499–511. [PubMed] [Google Scholar]
  10. Shalaby M. R., Aggarwal B. B., Rinderknecht E., Svedersky L. P., Finkle B. S., Palladino M. A., Jr Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors. J Immunol. 1985 Sep;135(3):2069–2073. [PubMed] [Google Scholar]
  11. Takahashi K., Watanuki Y., Yamazaki M., Abe S. Local induction of a cytotoxic factor in a murine tumour by systemic administration of an antitumour polysaccharide, MGA. Br J Cancer. 1988 Feb;57(2):170–173. doi: 10.1038/bjc.1988.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Vecchiarelli A., Cenci E., Puliti M., Blasi E., Puccetti P., Cassone A., Bistoni F. Protective immunity induced by low-virulence Candida albicans: cytokine production in the development of the anti-infectious state. Cell Immunol. 1989 Dec;124(2):334–344. doi: 10.1016/0008-8749(89)90135-4. [DOI] [PubMed] [Google Scholar]
  13. Wolf J. E., Massof S. E. In vivo activation of macrophage oxidative burst activity by cytokines and amphotericin B. Infect Immun. 1990 May;58(5):1296–1300. doi: 10.1128/iai.58.5.1296-1300.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]

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