Iproveratril: Experimental Data on Coronary Dilatation and Antiarrhythmic Action

Abstract

Various cardiovascular effects of a new synthetic coronary vasodilator, α-isopropyl-α [(N-methyl - N - homoveratryl)-γ-amino-propyl]-3, 4-dimethoxyphenylacetonitrile HCI (D365, Iproveratril or Isoptin) have been studied. In isolated perfused rabbit hearts the drug exerts a potent coronary vasodilator action, but can depress myocardial contractions and A-V conduction. In anesthetized cats it produces varying degrees of hypotension with bradycardia, and antagonizes ST-T changes induced by ouabain. It can also protect against chloroform-adrenaline and ouabain ventricular fibrillation. On isolated papillary muscle preparations it can lead to adrenergic blockade. It is concluded that in addition to its coronary dilator action, the drug exerts `quinidine-like' antiarrythmic effects, and appears to deserve further study.

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