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. 1997 Nov;71(11):8856–8859. doi: 10.1128/jvi.71.11.8856-8859.1997

Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator.

N Kato 1, K H Lan 1, S K Ono-Nita 1, Y Shiratori 1, M Omata 1
PMCID: PMC192353  PMID: 9343247

Abstract

The hepatitis C virus (HCV) nonstructural region 5A (NS5A) protein, without its 146 amino-terminal amino acids and fused to the DNA-binding domain of GAL4, strongly activates transcription in yeast and human hepatoma cells. Transcriptional activation by the HCV NS5A protein may play a role in viral replication and hepatocarcinogenesis.

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Selected References

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