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. 1997 Nov;71(11):8918–8922. doi: 10.1128/jvi.71.11.8918-8922.1997

Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells.

H Kaneko 1, L P Neoh 1, N Takeda 1, H Akimoto 1, T Hishikawa 1, H Hashimoto 1, S Hirose 1, S Karaki 1, M Takiguchi 1, H Nakauchi 1, Y Kaneko 1, N Yamamoto 1, I Sekigawa 1
PMCID: PMC192365  PMID: 9343259

Abstract

We report here that human immunodeficiency virus type 2 (HIV-2) envelope glycoprotein (gp105), but not HIV-1 gp120, can bind to CD8 molecules as well as to CD4 molecules on human T cells. This phenomenon may lead to differences in the life cycles of HIV-1 and HIV-2, and it may be related to the differences in disease manifestations of HIV-1 and HIV-2 infection, including longer survival of HIV-2-infected patients.

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Selected References

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