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. 1992 Sep;36(9):2054–2056. doi: 10.1128/aac.36.9.2054

Pseudomonas aeruginosa biofilm as a diffusion barrier to piperacillin.

B D Hoyle 1, J Alcantara 1, J W Costerton 1
PMCID: PMC192438  PMID: 1416900

Abstract

Pseudomonas aeruginosa 579 biofilms formed on dialysis membranes retarded piperacillin diffusion. Treatment of biofilms with 5.0 mM CaCl2.2H2O prevented diffusion. Biofilms permitted equilibration of [14C]glucose. Thin-layer chromatography of fluids distal to untreated (viable and nonviable) and viable Ca(2+)-treated P. aeruginosa 579 biofilms and fluids distal to a viable P. aeruginosa mutant noninducible for the expression of beta-lactamase did not detect piperacillinoic acid.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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