Abstract
A 45-year-old man developed, apparently simultaneously, two rare conditions, xanthomatosis (with hypercholesterolemia) and myelomatosis. His blood contained very high levels of cholesterol, the major part of which was present in a markedly elevated beta-lipoprotein fraction. Studies carried out over a period of six years, utilizing electrophoresis, ultracentrifugation, determinations of chemical composition and incorporation with C14-labelled glutamic acid and acetate, indicated a direct association between the two conditions, the myeloma lipoprotein apparently being produced by the abnormal plasma cells in the bone marrow. There were definite indications that the low density Sf 0-12 lipoproteins were primarily involved.
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