Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1993 Dec;37(12):2733–2735. doi: 10.1128/aac.37.12.2733

Antimicrobial susceptibilities of Gardnerella vaginalis.

A B Kharsany 1, A A Hoosen 1, J Van den Ende 1
PMCID: PMC192794  PMID: 8109944

Abstract

The in vitro susceptibilities of 93 clinical isolates of Gardnerella vaginalis to 25 antimicrobial agents were determined by the agar dilution method. All isolates were susceptible to penicillin, ampicillin, erythromycin, clindamycin, chloramphenicol, and trimethoprim. Activity was poor for vancomycin, LY146032, the cephalosporins, ciprofloxacin, and imipenem. Some resistance was observed with tetracycline and minocycline. The MICs of metronidazole paralleled those of tinidazole, with the hydroxymetabolite of metronidazole being the most active. One strain was resistant to all three agents. Marked resistance to aztreonam, amikacin, and sulfamethoxazole was observed.

Full text

PDF
2733

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berardi-Grassias L., Roy O., Berardi J. C., Furioli J. Neonatal meningitis due to Gardnerella vaginalis. Eur J Clin Microbiol Infect Dis. 1988 Jun;7(3):406–407. doi: 10.1007/BF01962348. [DOI] [PubMed] [Google Scholar]
  2. Criswell B. S., Marston J. H., Stenback W. A., Black S. H., Gardner H. L. Haemophilus vaginalis 594, a gram-negative organism? Can J Microbiol. 1971 Jul;17(7):865–869. doi: 10.1139/m71-139. [DOI] [PubMed] [Google Scholar]
  3. Durfee M. A., Forsyth P. S., Hale J. A., Holmes K. K. Ineffectiveness of erythromycin for treatment of Haemophilus vaginalis-associated vaginitis: possible relationship to acidity of vaginal secretions. Antimicrob Agents Chemother. 1979 Nov;16(5):635–637. doi: 10.1128/aac.16.5.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. GARDNER H. L., DUKES C. D. Haemophilus vaginalis vaginitis: a newly defined specific infection previously classified non-specific vaginitis. Am J Obstet Gynecol. 1955 May;69(5):962–976. [PubMed] [Google Scholar]
  5. Hillier S., Krohn M. A., Watts D. H., Wolner-Hanssen P., Eschenbach D. Microbiologic efficacy of intravaginal clindamycin cream for the treatment of bacterial vaginosis. Obstet Gynecol. 1990 Sep;76(3 Pt 1):407–413. [PubMed] [Google Scholar]
  6. Johnson A. P., Boustouller Y. L. Extra-vaginal infection caused by Gardnerella vaginalis. Epidemiol Infect. 1987 Apr;98(2):131–137. doi: 10.1017/s0950268800061835. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jones B. M., Geary I., Alawattegama A. B., Kinghorn G. R., Duerden B. I. In-vitro and in-vivo activity of metronidazole against Gardnerella vaginalis, Bacteroides spp. and Mobiluncus spp. in bacterial vaginosis. J Antimicrob Chemother. 1985 Aug;16(2):189–197. doi: 10.1093/jac/16.2.189. [DOI] [PubMed] [Google Scholar]
  8. LEOPOLD S. Heretofore undescribed organism isolated from the genitourinary system. U S Armed Forces Med J. 1953 Feb;4(2):263–266. [PubMed] [Google Scholar]
  9. Limbert M., Seibert G., Winkler I., Isert D., Klesel N., Markus A., Schrinner E. Antibacterial activity in vitro of cefpirome against clinical isolates causing sexually transmitted diseases. J Antimicrob Chemother. 1992 Apr;29 (Suppl A):13–17. doi: 10.1093/jac/29.suppl_a.13. [DOI] [PubMed] [Google Scholar]
  10. McCarthy L. R., Mickelsen P. A., Smith E. G. Antibiotic susceptibility of Haemophilus vaginalis (Corynebacterium vaginale) to 21 antibiotics. Antimicrob Agents Chemother. 1979 Aug;16(2):186–189. doi: 10.1128/aac.16.2.186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Pheifer T. A., Forsyth P. S., Durfee M. A., Pollock H. M., Holmes K. K. Nonspecific vaginitis: role of Haemophilus vaginalis and treatment with metronidazole. N Engl J Med. 1978 Jun 29;298(26):1429–1434. doi: 10.1056/NEJM197806292982601. [DOI] [PubMed] [Google Scholar]
  12. Ralph E. D., Amatnieks Y. E. Relative susceptibilities of Gardnerella vaginalis (Haemophilus vaginalis), Neisseria gonorrhoeae, and Bacteroides fragilis to Metronidazole and its two major metabolites. Sex Transm Dis. 1980 Oct-Dec;7(4):157–160. doi: 10.1097/00007435-198010000-00001. [DOI] [PubMed] [Google Scholar]
  13. Reimer L. G., Reller L. B. Gardnerella vaginalis bacteremia: a review of thirty cases. Obstet Gynecol. 1984 Aug;64(2):170–172. [PubMed] [Google Scholar]
  14. Reyn A., Birch-Andersen A., Lapage S. P. An electron microscope study of thin sections of Haemophilus vaginalis (Gardner and Dukes) and some possibly related species. Can J Microbiol. 1966 Dec;12(6):1125–1136. doi: 10.1139/m66-154. [DOI] [PubMed] [Google Scholar]
  15. Roberts M. C., Hillier S. L. Genetic basis of tetracycline resistance in urogenital bacteria. Antimicrob Agents Chemother. 1990 Feb;34(2):261–264. doi: 10.1128/aac.34.2.261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rousseau D., Harbec P. S. Delivery volumes of the 1- and 3-mm pins of a Cathra replicator. J Clin Microbiol. 1987 Jul;25(7):1311–1311. doi: 10.1128/jcm.25.7.1311-.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Sadhu K., Domingue P. A., Chow A. W., Nelligan J., Cheng N., Costerton J. W. Gardnerella vaginalis has a gram-positive cell-wall ultrastructure and lacks classical cell-wall lipopolysaccharide. J Med Microbiol. 1989 Jul;29(3):229–235. doi: 10.1099/00222615-29-3-229. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES