Abstract
Mammary cancer occurred in five of 80 ICR Swiss mice and two of 52 phenotypically normal pituitary dwarf strain mice following intravaginal applications of 20-methylcholanthrene in doses totalling 2.0 to 5.5 mg. Twenty-two of these 132 methylcholanthrene-treated mice had lower genital tract cancer. One acetone-treated Swiss mouse developed mammary cancer. No genital tract or mammary cancer occurred in mice receiving less than 2.0 mg. methylcholanthrene. The carcinogen was administered when mice were young; mammary cancers appeared between 65 and 167 days after methylcholanthrene application was begun. This study provides additional examples of carcinogenesis in organs remote from sites of carcinogen treatment with carcinogen doses close to threshold levels for treated tissues.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ANDERVONT H. B., DUNN T. B. Response of mammary-tumor-agent-free strain DBA female mice to percutaneous application of methylcholanthrene. J Natl Cancer Inst. 1950 Feb;10(4):895–925. [PubMed] [Google Scholar]
- BONSER G. M. The evolution of mammary cancer induced in virgin female IF mice with minimal doses of locally-acting methylcholanthrene. J Pathol Bacteriol. 1954 Oct;68(2):531–546. doi: 10.1002/path.1700680226. [DOI] [PubMed] [Google Scholar]
- CAMPBELL J. S., MAGNER D., FOURNIER P. Adenoacanthomas of ovary and uterus occuring as coexistent or sequential primary neoplasms. Cancer. 1961 Jul-Aug;14:817–826. doi: 10.1002/1097-0142(199007/08)14:4<817::aid-cncr2820140418>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
- Cantero A. Carcinogenesis: Mechanism and Criteria of Carcinogenic Activity. Can Med Assoc J. 1962 Sep 29;87(13):690–693. [PMC free article] [PubMed] [Google Scholar]
- GEYER R. P., BRYANT J. E., BLEISCH V. R., PEIRCE E. M., STARE F. J. Effect of dose and hormones on tumor production in rats given emulsified 9, 10-dimethyl-1,2-benzanthracene intravenously. Cancer Res. 1953 Jul;13(71):503–506. [PubMed] [Google Scholar]
- MARCHANT J. Chemical induction of breast tumours in mice of the C57B1 strain. The influence of pseudopregnancy, pregnancy and lactation on induction by methylcholanthrene. Br J Cancer. 1961 Sep;15:568–573. doi: 10.1038/bjc.1961.66. [DOI] [PMC free article] [PubMed] [Google Scholar]