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. 1965 May 22;92(21):1114–1116.

The Content of Antigens 1, 2 and 3 in Strains of Bordetella pertussis and in Vaccines

Norma Chalvardjian
PMCID: PMC1928309  PMID: 14285295

Abstract

A comparison was made of the content of heat-labile antigens 1, 2 and 3 in strains of Bordetella pertussis isolated in Toronto, and the content of the same antigens in vaccines being used in that community. Antisera were prepared in rabbits and made monospecific by absorptions. Antigens were detected by slide agglutination tests. Of the 58 strains examined, 56 contained antigens 1 and 3 but no antigen 2 was detected. Nine of these strains were isolated from children who had received a full course of vaccination and had subsequently developed pertussis. All 10 vaccines examined contained antigen 1; two, possibly four, contained no antigen 2; and seven of the 10 vaccines were weak or deficient in antigen 3. This work suggests that improved protection might be attained by the use of vaccines containing adequate amounts of all three antigens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COHEN H. H. DEVELOPMENT OF PERTUSSIS VACCINE PRODUCTION AND CONTROL IN THE NATIONAL INSTITUTE OF PUBLIC HEALTH IN THE NETHERLANDS DURING THE YEARS 1950--1962. Antonie Van Leeuwenhoek. 1963;29:183–201. doi: 10.1007/BF02046052. [DOI] [PubMed] [Google Scholar]
  2. EDSALL G., McCOMB J. A., WETTERLOW L. H., IPSEN J., Jr Significance of the loss of potency in the pertussin component of certain lots of "quadruple antigen". N Engl J Med. 1962 Oct 4;267:687–689. doi: 10.1056/NEJM196210042671403. [DOI] [PubMed] [Google Scholar]
  3. ELDERING G., EVELAND W. C., KENDRICK P. L. Fluorescent antibody staining and agglutination reactions in Bordetella pertussis cultures. J Bacteriol. 1962 Apr;83:745–749. doi: 10.1128/jb.83.4.745-749.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. ELDERING G., HORNBECK C., BAKER J. Serological study of Bordetella pertussis and related species. J Bacteriol. 1957 Aug;74(2):133–136. doi: 10.1128/jb.74.2.133-136.1957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. OLSON B. H., ELDERING G., GRAHAM B. STABILIZATION OF PERTUSSIS VACCINE IN THE PRESENCE OF BENZETHONIUM CHLORIDE. J Bacteriol. 1964 Mar;87:543–546. doi: 10.1128/jb.87.3.543-546.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. PILLEMER L., BLUM L., LEPOW I. H. Protective antigen of haemophilus pertussis. Lancet. 1954 Jun 19;266(6825):1257–1260. doi: 10.1016/s0140-6736(54)92770-1. [DOI] [PubMed] [Google Scholar]
  7. PRESTON N. W., EVANS P. Type-specific immunity against intracerebral pertussis infection in mice. Nature. 1963 Feb 2;197:508–509. doi: 10.1038/197508a0. [DOI] [PubMed] [Google Scholar]
  8. PRESTON N. W., TE PUNGA W. A. The relation between agglutinin production by pertussis vaccines and their immunising potency in mice. J Pathol Bacteriol. 1959 Jul;78:209–216. doi: 10.1002/path.1700780123. [DOI] [PubMed] [Google Scholar]
  9. PRESTON N. W. TYPE-SPECIFIC IMMUNITY AGAINST WHOOPING-COUGH. Br Med J. 1963 Sep 21;2(5359):724–726. doi: 10.1136/bmj.2.5359.724. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. PROVENZANO R. W., WETTERLOW L. H., IPSEN J. Pertussis immunization in pediatric practice and in public health. N Engl J Med. 1959 Sep 3;261:473–478. doi: 10.1056/NEJM195909032611001. [DOI] [PubMed] [Google Scholar]
  11. SUTHERLAND I. W. The protective activity of components of Bordetella pertussis cell walls. Immunology. 1963 May;6:246–254. [PMC free article] [PubMed] [Google Scholar]
  12. WILSON R. J. Canada's experience with multiple antigens. Can J Public Health. 1962 Nov;53:457–462. [PubMed] [Google Scholar]

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