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. 1965 Jun 19;92(25):1292–1297.

The Acute Toxicity of Tannic Acid Administered Intragastrically

Eldon M Boyd
PMCID: PMC1928430  PMID: 14291458

Abstract

The LD50 ± S.E. of tannic acid given orally to albino rats was found to be 2.26±0.083 g. per kg. body weight, which is higher than its apparent LD50 when given per rectum. The immediate cause of death was respiratory failure preceded by convulsions when death occurred early and by hypothermic cachexia when death was delayed. Death was associated with a progressively developing hepatic necrosis and nephritis and a temporary acute gastroenteritis. It was accompanied by loss of weight and edema in many organs, evidence of stimulation of the spleen, adrenal cortex and testes, and atrophy of the thymus. Recovery in survivors was associated with a temporary increase in weight of the spleen and testes and persistence of loss of weight in the adrenal, pyloric stomach, and skin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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