Skip to main content
NCBI home page
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1970 Aug 15;103(4):343–348.

Chromosome Studies in Selected Spontaneous Abortions: 1. Conception After Oral Contraceptives

D H Carr
PMCID: PMC1930439  PMID: 5447713

Abstract

Fifty-four abortuses from women who conceived within six months of discontinuing oral contraceptives were collected over a 2½-year period. Chromosome analysis of the abortuses showed an increase in triploidy which was highly significant statistically when compared with a control series. Triploidy is virtually always lethal early in embryonic life. Tetraploidy was also increased, but the numbers were too small for analysis. The chromosome disorders which are compatible with livebirth (trisomy and X-monosomy) were not increased in the post-oral-contraceptive abortuses. It is suggested that there is a temporary hormonal imbalance in some women after they discontinue oral contraceptives. This could affect the timing of fertilization. Triploidy could arise at the first or second meiotic division of the ovum or at fertilization. Abortuses are a valuable source of information relating to congenital defects.

Full text

PDF
343

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beaconsfield P., Ginsburg J. Oral contraceptives and cell replication. Lancet. 1968 Mar 16;1(7542):592–592. doi: 10.1016/s0140-6736(68)92860-2. [DOI] [PubMed] [Google Scholar]
  2. Bishop P. F., Hill H. Oral contraceptives and cell replication. Lancet. 1968 Mar 30;1(7544):693–693. doi: 10.1016/s0140-6736(68)92135-1. [DOI] [PubMed] [Google Scholar]
  3. Carr D. H., Bateman A. J., Murray A. B. Analysis of data from abortuses which failed to grow in culture. Obstet Gynecol. 1966 Nov;28(5):611–614. [PubMed] [Google Scholar]
  4. Carr D. H. Chromosome anomalies as a cause of spontaneous abortion. Am J Obstet Gynecol. 1967 Feb 1;97(3):283–293. doi: 10.1016/0002-9378(67)90488-7. [DOI] [PubMed] [Google Scholar]
  5. Carr D. H. Cytogenetics and the pathology of hydatidiform degeneration. Obstet Gynecol. 1969 Mar;33(3):333–342. [PubMed] [Google Scholar]
  6. Flowers C. E., Jr, Vorys N., Stevens V., Miller A. T., Jensen L. The effects of suppression of menstruation with ethynodiol diacetate upon the pituitary, ovary, and endometrium. Am J Obstet Gynecol. 1966 Nov 15;96(6):784–803. doi: 10.1016/0002-9378(66)90675-2. [DOI] [PubMed] [Google Scholar]
  7. Hedberg E., Holmdahl K., Pehrson S. On relationship between maternal health and congenital malformations. Acta Obstet Gynecol Scand. 1967;46(3):378–391. doi: 10.3109/00016346709158641. [DOI] [PubMed] [Google Scholar]
  8. Lejeune J., Salmon C., Berger R., Réthoré M. O., Rossier A., Job J. C. Chimère 46,XX-69,XXY. Ann Genet. 1967 Dec;10(4):188–192. [PubMed] [Google Scholar]
  9. Lopez-Llera M., Alvarado-Duran A., Rubio G., Carbia E. Ovarian morphogenesis in the first spontaneous cycles after prolonged oral contraception. Int J Fertil. 1969 Apr-Jun;14(2):162–173. [PubMed] [Google Scholar]
  10. Maruffo C. A. Zona pellucida of rhesus monkey ovum after gonadotropin stimulation. Science. 1967 Sep 15;157(3794):1313–1314. doi: 10.1126/science.157.3794.1313. [DOI] [PubMed] [Google Scholar]
  11. Mears E. Pregnancy following antifertility agents. Int J Fertil. 1968 Oct-Dec;13(4):340–345. [PubMed] [Google Scholar]
  12. Poland B. J. Conception control and embryonic development. Am J Obstet Gynecol. 1970 Feb 1;106(3):365–368. doi: 10.1016/0002-9378(70)90361-3. [DOI] [PubMed] [Google Scholar]
  13. Seigel D., Corfman P. Epidemiological problems associated with studies of the safety of oral contraceptives. JAMA. 1968 Mar 11;203(11):950–954. [PubMed] [Google Scholar]
  14. Shaver E. L., Carr D. H. The chromosome complement of rabbit blastocysts in relation to the time of mating and ovulation. Can J Genet Cytol. 1969 Jun;11(2):287–293. doi: 10.1139/g69-036. [DOI] [PubMed] [Google Scholar]
  15. Shojania A. M., Hornady G., Barnes P. H. Oral contraceptives and folate metabolism. Lancet. 1969 Apr 26;1(7600):886–886. doi: 10.1016/s0140-6736(69)91923-0. [DOI] [PubMed] [Google Scholar]
  16. Singh O. S., Carr D. H. A study of the effects of certain hormones on human cells in culture. Can Med Assoc J. 1970 Aug 15;103(4):349–350. [PMC free article] [PubMed] [Google Scholar]
  17. Singh R. P., Carr D. H. Anatomic findings in human abortions of known chromosomal constitution. Obstet Gynecol. 1967 Jun;29(6):806–818. [PubMed] [Google Scholar]
  18. Singh R. P., Carr D. H. Congenital anomalies in embryos with normal chromosomes. Biol Neonat. 1968;13(1):121–128. doi: 10.1159/000240139. [DOI] [PubMed] [Google Scholar]
  19. Singh R. P., Carr D. H. The anatomy and histology of XO human embryos and fetuses. Anat Rec. 1966 Jul;155(3):369–383. doi: 10.1002/ar.1091550309. [DOI] [PubMed] [Google Scholar]
  20. Starup J. The effect of gestagen and oestrogen treatment on the development of ovarian follicles: laboratory observations. Acta Obstet Gynecol Scand. 1967;46(Suppl):15–23. doi: 10.3109/00016346709156832. [DOI] [PubMed] [Google Scholar]
  21. Swerdloff R. S., Odell W. D. Serum luteinizing and follicle stimulating hormone levels during sequential and nonsequential contraceptive treatment of eugonadal women. J Clin Endocrinol Metab. 1969 Feb;29(2):157–163. doi: 10.1210/jcem-29-2-157. [DOI] [PubMed] [Google Scholar]
  22. Wagner D., Richart R. M. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol. 1968 May;85(5):475–480. [PubMed] [Google Scholar]
  23. Williams D. L., Runyan J. W., Hagen A. A. Meiotic chromosome alterations produced by progesterone. Nature. 1968 Dec 14;220(5172):1145–1147. doi: 10.1038/2201145a0. [DOI] [PubMed] [Google Scholar]
  24. York E. Post-flight discomfort in aviators: aero atelectasis. Aerosp Med. 1967 Feb;38(2):192–194. [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES