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. 1970 Nov 21;103(11):1157–1160.

The Role of Rubella in the Etiology of Supravalvular Aortic Stenosis

Dennis J Vince
PMCID: PMC1930619  PMID: 5489321

Abstract

The possibility of an etiological relationship between rubella embryopathy and sporadic forms of supravalvular aortic stenosis is considered. A case is presented of a patient with rubella embryopathy and supravalvular aortic stenosis associated with pulmonary valvular and peripheral pulmonary artery stenosis, bicuspid aortic valve, aortic valve stenosis and subendothelial myocardial fibrosis. A review of the literature revealed many clinical and pathological features common to both syndromes. The hypothesis that rubella virus produced germ-cell mutation and subsequent persistence of rubella in the zygote produced further fetal damage is presented to explain these observations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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