Abstract
Two cases of malignant disease occurring during immunosuppressive therapy, one a leiomyosarcoma of bowel metastatic to the liver, the other, carcinoma in situ of the cervix uteri, are reported. The possible roles of immunosuppression and immunosuppressive therapy in the pathogenesis of these neoplasms are discussed. It is suggested that the incidence of neoplasms in immunologically suppressed patients is greatly increased and that further investigation into the relation of immunosuppression to cancer is urgently needed.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Burnet F. M. Immunological aspects of malignant disease. Lancet. 1967 Jun 3;1(7501):1171–1174. doi: 10.1016/s0140-6736(67)92837-1. [DOI] [PubMed] [Google Scholar]
- Doane F. W., Anderson N., Zbitnew A., Rhodes A. J. Application of electron microscopy to the diagnosis of virus infections. Can Med Assoc J. 1969 Jun 14;100(22):1043–1049. [PMC free article] [PubMed] [Google Scholar]
- EPSTEIN M. A., ACHONG B. G., BARR Y. M. VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. Lancet. 1964 Mar 28;1(7335):702–703. doi: 10.1016/s0140-6736(64)91524-7. [DOI] [PubMed] [Google Scholar]
- Edelman R., Wheelock E. F. Enhancement of replication of vesicular stomatitis virus in human lymphocyte cultures treated with heterologous anti-lymphocyte serum. Lancet. 1968 Apr 13;1(7546):771–775. doi: 10.1016/s0140-6736(68)92226-5. [DOI] [PubMed] [Google Scholar]
- Goldenberg G. J., Paraskevas F., Israels L. G. The association of rheumatoid arthritis with plasma cell and lymphocytic neoplasms. Arthritis Rheum. 1969 Dec;12(6):569–579. doi: 10.1002/art.1780120604. [DOI] [PubMed] [Google Scholar]
- Gupta P. K., Pinn V. M., Taft P. D. Cervical dysplasia associated with azathioprine (Imuran) therapy. Acta Cytol. 1969 Jul;13(7):373–376. [PubMed] [Google Scholar]
- Jensen M. K., Soborg M. Chromosome aberrations in human cells following treatment with imuran. Preliminary report. Acta Med Scand. 1966 Feb;179(2):249–250. doi: 10.1111/j.0954-6820.1966.tb05454.x. [DOI] [PubMed] [Google Scholar]
- Koss L. G., Melamed M. R., Mayer K. The effect of busulfan on human epithelia. Am J Clin Pathol. 1965 Oct;44(4):385–397. doi: 10.1093/ajcp/44.4.385. [DOI] [PubMed] [Google Scholar]
- Morton D. L., Hall W. T., Malmgren R. A. Human liposarcomas: tissue cultures containing foci of transformed cells with viral particles. Science. 1969 Aug 22;165(3895):813–816. doi: 10.1126/science.165.3895.813. [DOI] [PubMed] [Google Scholar]
- Morton D. L., Malmgren R. A., Hall W. T., Schidlovsky G. Immunologic and virus studies with human sarcomas. Surgery. 1969 Jul;66(1):152–161. [PubMed] [Google Scholar]
- RICHART R. M. A RADIOAUTOGRAPHIC ANALYSIS OF CELLULAR PROLIFERATION IN DYSPLASIA AND CARCINOMA IN SITU OF THE UTERINE CERVIX. Am J Obstet Gynecol. 1963 Aug 1;86:925–930. doi: 10.1016/s0002-9378(16)35248-6. [DOI] [PubMed] [Google Scholar]
- Sell S. Antilymphocytic antibody: effects in experimental animals and problems in human use. Ann Intern Med. 1969 Jul;71(1):177–196. doi: 10.7326/0003-4819-71-1-177. [DOI] [PubMed] [Google Scholar]