Skip to main content
NCBI home page
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1972 Jan 8;106(1):32–35.

Hepatitis-associated antigen in sporadic cases of acute viral hepatitis

A E Kelen, A E Hathaway, D A McLeod, F P Nagler
PMCID: PMC1931364  PMID: 4333004

Abstract

Serum specimens collected during the period from September 1970 to April 1971 from hospitalized patients and apparently healthy staff members at risk were tested for the presence of hepatitis-associated antigen (HAA) by the parallel use of three techniques: the complement fixation test, crossover-electrophoresis and immuno-electronmicroscopy.

Out of a total of 204 persons investigated 63 (30.9%) were found to harbour the antigen. The HAA-positive sera originated almost exclusively from sporadic cases of acute viral hepatitis (clinically diagnosed as “infectious hepatitis” or “serum hepatitis”). The great majority of the hepatitis cases studied had a history of drug addiction.

Full text

PDF
32

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahmed M. N., Huang S., Spence L. Australia antigen and hepatitis. An electron microscopic study. Arch Pathol. 1971 Jul;92(1):66–72. [PubMed] [Google Scholar]
  2. BLUMBERG B. S., ALTER H. J., VISNICH S. A "NEW" ANTIGEN IN LEUKEMIA SERA. JAMA. 1965 Feb 15;191:541–546. doi: 10.1001/jama.1965.03080070025007. [DOI] [PubMed] [Google Scholar]
  3. Kelen A. E., Hathaway A. E., McLeod D. A. Rapid detection of Australia-SH antigen and antibody by a simple and sensitive technique of immunoelectronmicroscopy. Can J Microbiol. 1971 Jul;17(7):993–1000. doi: 10.1139/m71-157. [DOI] [PubMed] [Google Scholar]
  4. Krugman S., Giles J. P., Hammond J. Infectious hepatitis. Evidence for two distinctive clinical, epidemiological, and immunological types of infection. JAMA. 1967 May 1;200(5):365–373. doi: 10.1001/jama.200.5.365. [DOI] [PubMed] [Google Scholar]
  5. Krugman S., Giles J. P. Viral hepatitis. New light on an old disease. JAMA. 1970 May 11;212(6):1019–1029. doi: 10.1001/jama.212.6.1019. [DOI] [PubMed] [Google Scholar]
  6. Le Bouvier G. L. The heterogeneity of Australia antigen. J Infect Dis. 1971 Jun;123(6):671–675. doi: 10.1093/infdis/123.6.671. [DOI] [PubMed] [Google Scholar]
  7. London W. T., Di Figlia M., Sutnick A., Blumberg B. S. An epidemic of hepatitis in a chronic-hemodialysis unit. Australia antigen and differences in host response. N Engl J Med. 1969 Sep 11;281(11):571–578. doi: 10.1056/NEJM196909112811101. [DOI] [PubMed] [Google Scholar]
  8. McCollum R. W. Serum antigens in viral hepatitis. J Infect Dis. 1969 Nov;120(5):641–643. doi: 10.1093/infdis/120.5.641. [DOI] [PubMed] [Google Scholar]
  9. Prince A. M. An antigen detected in the blood during the incubation period of serum hepatitis. Proc Natl Acad Sci U S A. 1968 Jul;60(3):814–821. doi: 10.1073/pnas.60.3.814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Prince A. M. Role of serum hepatitis virus in chronic liver disease. Gastroenterology. 1971 May;60(5):913–921. [PubMed] [Google Scholar]
  11. Shulman N. R. Hepatitis-associated antigen. Am J Med. 1970 Nov;49:669–692. doi: 10.1016/S0002-9343(70)80133-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Turner G. C., White G. B. S.H. antigen in haemodialysis-associated hepatitis. Lancet. 1969 Jul 19;2(7612):121–124. [PubMed] [Google Scholar]
  13. Viral hepatitis and tests for the Australia (hepatitis-associated) antigen and antibody. Bull World Health Organ. 1970;42(6):957–992. [PMC free article] [PubMed] [Google Scholar]
  14. Zalan E., Hamvas J. J., Tobe B. A., Kuderewko O., Labzoffsky N. A. Association of virus-like particles with Australia antigen in serum of patients with serum hepatitis. Can Med Assoc J. 1971 Jan 23;104(2):145–147. [PMC free article] [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES