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. 1993 Mar;175(5):1537–1542. doi: 10.1128/jb.175.5.1537-1542.1993

Peptidoglycan tripeptide content and cross-linking are altered in Enterobacter cloacae induced to produce AmpC beta-lactamase by glycine and D-amino acids.

A C Ottolenghi 1, M Caparrós 1, M A de Pedro 1
PMCID: PMC193244  PMID: 8444815

Abstract

Induction of AmpC beta-lactamase in Enterobacter cloacae ATCC 13047 by D-methionine, glycine, or D-tryptophan was accompanied by alterations in peptidoglycan composition and structure; in the case of D-methionine, it was also accompanied by morphologic changes. A decrease in peptidoglycan tripeptides was seen. With glycine, there was an increase in the proportion of diaminopimelic-diaminopimelic cross-links. The possible implications of these changes for beta-lactamase induction are discussed.

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Selected References

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