N-Terminal Mutants of Herpes Simplex Virus Type 2 gH Are Transported without gL but Require gL for Function

Volume 81, no. 10, p. 5102-5111, 2007. Just prior to publication, we discovered that the L72A mutant clone used in our study contained an additional mutation in gH2 (F163L). It is unclear at this time whether the structural and functional defect we see with our clone is due to the F163L mutation, the L72A mutation, or a combination of the two amino acid changes. This finding does not diminish the fact that the other mutations to the N-terminal region of gH2 described in this paper (Δ64, Δ72, Δ48-71, Δ48-63, Δ62-72, and L66A) affect gH/gL function. F163 lies in an unstudied region of gH2. We are addressing this issue.