Abstract
A clinical trial was carried out with the object of comparing the effects of furosemide, a new oral diuretic agent, with those of mercaptomerin and hydrochlorothiazide. Eleven edematous patients were chosen for the study and the diuretics were rotated, each drug being preceded by a one- to three-day control period. The patients served as their own controls. Urine electrolytes, body weight, and blood chemistry were monitored.
Furosemide was shown to be an effective diuretic in this clinical study; under the conditions of the trial a single oral dose of 80 mg. of furosemide produced a natriuretic response in a 24-hour period equivalent to that achieved with a single oral dose of 100 mg. of hydrochlorothiazide or a single dose of 2.0 c.c. (80 mg. of mercury) of mercaptomerin given intramuscularly.
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