Abstract
Experimental and epidemiological evidence has implicated environmental factors in the increasing incidence of bladder cancer. Papillary tumours are less malignant than solid. Of 36 patients with papillary growths in the renal pelvis, 20 lived five years but 11 of 15 with solid tumours died within one year.
Social and geographical influences have affected the incidence of adenocarcinoma of the kidney. Experimentally it has been produced by hormones, carcinogens, viruses and irradiation. Clinically the most adverse factor was histological anaplasia; renal vein invasion was three times as common in high-grade tumours. The postoperative five-year survival was 30 out of 42 patients with low-grade lesions but 12 out of 42 with high-grade lesions. In the case of low malignancy tumours without adverse factors, 25 out of 29 patients survived for five years. This unpredictable behaviour is characteristic of urinary tract tumours.
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Selected References
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- BOYLAND E., HARRIS J., HORNING E. S. The induction of carcinoma of the bladder in rats with acetamidofluorene. Br J Cancer. 1954 Dec;8(4):647–654. doi: 10.1038/bjc.1954.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Broders A. C. EPITHELIOMA OF THE GENITO-URINARY ORGANS. Ann Surg. 1922 May;75(5):574–604. doi: 10.1097/00000658-192205000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CASE R. A. Cohort analysis of cancer mortality in England and Wales; 1911-1954 by site and sex. Br J Prev Soc Med. 1956 Oct;10(4):172–199. doi: 10.1136/jech.10.4.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COBB B. G., ANSELL J. S. CIGARETTE SMOKING AND CANCER OF THE BLADDER. JAMA. 1965 Aug 2;193:329–332. doi: 10.1001/jama.1965.03090050005001. [DOI] [PubMed] [Google Scholar]
- DUKES C. E. Clues to the causes of cancer of the kidney. Lancet. 1961 Nov 25;2(7213):1157–1163. doi: 10.1016/s0140-6736(61)90839-x. [DOI] [PubMed] [Google Scholar]
- JOMAIN J. [The limitations of nephrectomy in cancer of the kidney in the adult. difficulties and impossibilities in terms of approach]. Mem Acad Chir (Paris) 1963 May 15;89:520–525. [PubMed] [Google Scholar]
- Lea A. J. Cigarette smoking and cancer of the lungs and of the bladder. Lancet. 1966 Mar 12;1(7437):590–591. doi: 10.1016/s0140-6736(66)90780-x. [DOI] [PubMed] [Google Scholar]
- NAIRN R. C., RICHMOND H. G., McENTEGART M. G., FOTHERGILL J. E. Immunological differences between normal and malignant cells. Br Med J. 1960 Nov 5;2(5209):1335–1340. doi: 10.1136/bmj.2.5209.1335. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PAGE B. H., RICHES E. W. Transitional-cell carcinoma of the colon following cystectomy and uretero-sigmoidostomy for carcinoma of the bladder. Br J Urol. 1956 Sep;28(3):288–291. doi: 10.1111/j.1464-410x.1956.tb04774.x. [DOI] [PubMed] [Google Scholar]
- PAVONE-MACALUSO M. [The etiology and pathogenesis of tumors of the kidney. Experimental tumors]. Gaz Med Fr. 1963 Apr 10;70:1143–1189. [PubMed] [Google Scholar]
- RICHES E. W. The place of total cystectomy in the treatment of bladder growth. Ann R Coll Surg Engl. 1956 Mar;18(3):178–200. [PMC free article] [PubMed] [Google Scholar]
- SCOTT W. W., BOYD H. L. A study of the carcinogenic effect of beta-naphthylamine on the normal and substituted isolated sigmoid loop bladder of dogs. J Urol. 1953 Dec;70(6):914–925. doi: 10.1016/S0022-5347(17)68005-4. [DOI] [PubMed] [Google Scholar]
- ZOLLINGER H. U. Durch chronische Bleivergiftung erzeugte Nierenadenome und -carcinome bei Ratten und ihre Beziehungen zu den entsprechenden Neubildungen des Menschen. Virchows Arch Pathol Anat Physiol Klin Med. 1953;323(6):694–710. doi: 10.1007/BF00956266. [DOI] [PubMed] [Google Scholar]