Abstract
The methods used for both pre-exposure and post-exposure immunization against rabies were studied. In pre-exposure immunization duck embryo vaccine should be used. In post-exposure immunization either duck embryo or Semple-type vaccine appears to be effective in stimulating antibody production. Both vaccines may cause neurological sequelae. A dose of vaccine should be given 20-50 days after completion of the primary course of vaccination. Immune serum should be used in all severe exposures especially of the head and neck, and in individuals in whom the commencement of vaccination has been unduly delayed. In individuals who have been previously vaccinated reinforcing doses have been found to be effective even as long as 20 years after the primary vaccination. A tissue culture vaccine has been developed and is about to undergo field trials.
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- CULBERTSON C. G., PECK F. B., Jr, POWELL H. M. Duck-embryo rabies vaccine; study of fixed virus vaccine grown in embryonated duck eggs and killed with beta-propiolactone (BPL). J Am Med Assoc. 1956 Dec 8;162(15):1373–1376. [PubMed] [Google Scholar]
- DIETERICH W. H., SHELTON D. F., JENEVEIN E. P., Jr Pre-exposure rabies immunization in man using duck-embryo vaccine. J Am Vet Med Assoc. 1961 Nov 1;139:999–1004. [PubMed] [Google Scholar]
- GARDNER S. D., ROBSON T. W. IMMUNITY TO RABIES FOLLOWING VACCINATION. Mon Bull Minist Health Public Health Lab Serv. 1964 Dec;23:235–237. [PubMed] [Google Scholar]
- GIBBS F. A., GIBBS E. L., CARPENTER P. R., SPIES H. W. Comparison of rabies vaccines grown on duck embryo and on nervous tissue. An electroencephalographic study. N Engl J Med. 1961 Nov 16;265:1002–1003. doi: 10.1056/NEJM196111162652008. [DOI] [PubMed] [Google Scholar]
- GREENBERG M., CHILDRESS J. Vaccination against rabies with duck-embryo and Semple vaccines. J Am Med Assoc. 1960 May 28;173:333–337. doi: 10.1001/jama.1960.03020220007002. [DOI] [PubMed] [Google Scholar]
- PECK F. B., Jr, POWELL H. M., CULBERTSON C. G. A new antirabies vaccine for human use; clinical and laboratory results using rabies vaccine made from embryonated duck eggs. J Lab Clin Med. 1955 May;45(5):679–683. [PubMed] [Google Scholar]
- SABETI A., BAHMANYAR M., GHODSSI M., BALTAZARD M. TRAITEMENT DES MORDUS PAR LOUPS ENRAG'ES EN IRAN. SITUATION ACTUELLE. Ann Inst Pasteur (Paris) 1964 Feb;106:303–307. [PubMed] [Google Scholar]
- STEELE J. H. RABIES--AN OLD PROBLEM PRESENTS A NEW CHALLENGE. J Am Vet Med Assoc. 1964 Aug 1;145:263–264. [PubMed] [Google Scholar]