Abstract
A case of hepatoma induced by thorium dioxide (Thorotrast) is reported. The literature concerning neoplasia associated with this agent is reviewed, with emphasis on the long latent period before the development of these tumours and the equally long latent period which preceded the recognition of their iatrogenic nature.
In particular, this report is intended to illustrate the diagnosis of such tumours on radiological and histological findings, provided that one is aware of their existence and familiar with the distribution and appearance of thorium dioxide deposits in the tissues. Such a diagnosis can be made without a history of thorium dioxide administration, which often may not be available.
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- BAKER H. D., DAVSON J., PAGET G. E. Haemangio-endothelioma (Kupffer-cell sarcoma) of the liver. J Pathol Bacteriol. 1956 Jul;72(1):173–182. doi: 10.1002/path.1700720123. [DOI] [PubMed] [Google Scholar]
- BASERGA R., YOKOO H., HENEGAR G. C. Thorotrast-induced cancer in man. Cancer. 1960 Sep-Oct;13:1021–1031. doi: 10.1002/1097-0142(196009/10)13:5<1021::aid-cncr2820130524>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
- BUDA J. A., CONLEY J. J., RANKOW R. CARCINOMA OF THE MAXILLARY SINUS FOLLOWING THOROTRAST INSTILLATION. A FURTHER REPORT. Am J Surg. 1963 Nov;106:868–871. doi: 10.1016/0002-9610(63)90417-3. [DOI] [PubMed] [Google Scholar]
- BUDIN E., GERSHON-COHEN J. The danger of cancer from thorotrast as a diagnostic medium. Am J Roentgenol Radium Ther Nucl Med. 1956 Jun;75(6):1188–1193. [PubMed] [Google Scholar]
- DA HORTA J. S. Late lesions in man caused by colloidal thorium dioxide (thorotrast); a new case of sarcoma of the liver twenty-two years after the injection. AMA Arch Pathol. 1956 Nov;62(5):403–418. [PubMed] [Google Scholar]
- DAHLGREN S. Thorotrast tumours. A review of the literature and report of two cases. Acta Pathol Microbiol Scand. 1961;53:147–161. [PubMed] [Google Scholar]
- GARDNER D. L., OGILVIE R. F. The late results of injection of thorotrast: two cases of neoplastic disease following contrast angiography. J Pathol Bacteriol. 1959 Jul;78:133–144. doi: 10.1002/path.1700780114. [DOI] [PubMed] [Google Scholar]
- HASSLER O., BOSTROEM K., DAHLBAECK L. O. THOROTRAST TUMOURS. Acta Pathol Microbiol Scand. 1964;61:13–20. doi: 10.1111/apm.1964.61.1.13. [DOI] [PubMed] [Google Scholar]
- LOONEY W. B., COLODZIN M. Late follow-up studies after internal deposition of radioactive materials. J Am Med Assoc. 1956 Jan 7;160(1):1–3. doi: 10.1001/jama.1956.02960360003001. [DOI] [PubMed] [Google Scholar]
- LOONEY W. B. Late clinical changes following the internal deposition of radioactive materials. Ann Intern Med. 1955 Feb;42(2):378–387. doi: 10.7326/0003-4819-42-2-378. [DOI] [PubMed] [Google Scholar]
- MORGAN A. D., JAYNE W. H., MARRACK D. Primary liver cell carcinoma 24 years after intravenous injection of thorotrast. J Clin Pathol. 1958 Jan;11(1):7–18. doi: 10.1136/jcp.11.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Macmahon H. E., Murphy A. S., Bates M. I. Endothelial-Cell Sarcoma of Liver Following Thorotrast Injections. Am J Pathol. 1947 Jul;23(4):585–611. [PMC free article] [PubMed] [Google Scholar]
- Suckow E. E., Henegar G. C., Baserga R. Tumors of the Liver Following Administration of Thorotrast. Am J Pathol. 1961 Jun;38(6):663–677. [PMC free article] [PubMed] [Google Scholar]
- THOMAS S. F., HENRY G. W., KAPLAN H. S. Hepatolienography; past, present, and future. Radiology. 1951 Nov;57(5):669–684. doi: 10.1148/57.5.669. [DOI] [PubMed] [Google Scholar]
- VERNER J. V., Jr, SMITH A. G. Hodgkin's disease following administration of thorotrast. South Med J. 1963 May;56:524–528. doi: 10.1097/00007611-196305000-00015. [DOI] [PubMed] [Google Scholar]