*From the Department of Pathology, University of Toronto, Toronto.
Based on a lecture delivered at Notre Dame Hospital, Montreal, on March 17, 1959. The postgraduate lecture series “Collagen Diseases” was sponsored by Charles E. Frosst & Co., Montreal.
The personal findings presented in Part I of this paper represent studies in progress, supported by a grant-in-aid from the Canadian Arthritis and Rheumatism Society; those in Parts II and III represent work carried out between 1953 and 1956 at Queen's University, Kingston, Ontario.