Skip to main content
PMC home page
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1972 Feb 19;106(4):331–335.

Inactivation of isoniazid by Canadian Eskimos and Indians

C W L Jeanes, O Schaefer, L Eidus
PMCID: PMC1940416  PMID: 5061127

Abstract

Phenotyping for isoniazid inactivation in Canadian Eskimos and Indians showed that the former are all fast acetylators, while only 63.4% of the Indians examined belonged to the same group. Further studies are suggested to confirm this initial finding.

During the investigation metabolic studies were carried out to devise a reliable urine test for phenotyping of isoniazid inactivators, to replace the fall-off technique which required venipunctures. The simplicity of the new urine test makes it suitable for mass examinations.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARMSTRONG A. R., PEART H. E. A comparison between the behavior of Eskimos and non-Eskimos to the administration of isoniazid. Am Rev Respir Dis. 1960 Apr;81:588–594. doi: 10.1164/arrd.1960.81.4.588. [DOI] [PubMed] [Google Scholar]
  2. DUFOUR A. P., KNIGHT R. A., HARRIS H. W. GENETICS OF ISONIAZID METABOLISM IN CAUCASIAN, NEGRO, AND JAPANESE POPULATIONS. Science. 1964 Jul 24;145(3630):391–391. [PubMed] [Google Scholar]
  3. EIDUS L., HAMILTON E. J. A NEW METHOD FOR THE DETERMINATION OF N-ACETYL ISONIAZID IN URINE OF AMBULATORY PATIENTS. Am Rev Respir Dis. 1964 Apr;89:587–588. doi: 10.1164/arrd.1964.89.4.587. [DOI] [PubMed] [Google Scholar]
  4. Eidus L., Harnanansingh A. M. A more sensitive spectrophotometric method for determination of isoniazid in serum or plasma. Clin Chem. 1971 Jun;17(6):492–494. [PubMed] [Google Scholar]
  5. Eidus L., Harnanansingh A. M., Jessamine A. G. Urine test for phenotyping isoniazid inactivators. Am Rev Respir Dis. 1971 Oct;104(4):587–591. doi: 10.1164/arrd.1971.104.4.587. [DOI] [PubMed] [Google Scholar]
  6. HARRIS H. W., KNIGHT R. A., SELIN M. J. Comparison of isoniazid concentrations in the blood of people of Japanese and European descent; therapeutic and genetic implications. Am Rev Tuberc. 1958 Dec;78(6):944–948. doi: 10.1164/artpd.1958.78.6.944. [DOI] [PubMed] [Google Scholar]
  7. Hanngren A., Borgå O., Sjöqvist F. Inactivation of isoniazid (INH) in Swedish tuberculous patients before and during treatment with para-aminosalicylic acid (PAS). Scand J Respir Dis. 1970;51(1):61–69. [PubMed] [Google Scholar]
  8. IWAINSKY H., GERLOFF W., SCHMIEDEL A. [The differentiation between isoniazid-inactivating and normally catabolizing patients by means of a simple test]. Beitr Klin Tuberk Spezif Tuberkuloseforsch. 1961;124:384–389. [PubMed] [Google Scholar]
  9. IWAINSKY H., KAUFFMANN G. W., SIEGEL D., GERISCHER C. [On the effect of INH metabolism on the therapy of pulmonary tuberculosis]. Beitr Klin Tuberk Spezif Tuberkuloseforsch. 1960;122:324–332. [PubMed] [Google Scholar]
  10. JESSAMINE A. G., HAMILTON E. J., EIDUS L. A CLINICAL STUDY OF ISONIAZID INACTIVATION. Can Med Assoc J. 1963 Dec 14;89:1214–1217. [PMC free article] [PubMed] [Google Scholar]
  11. MAIER N., MOISESCU V. EINE SCHNELLE METHODE ZUR BESTIMMUNG DER KONZENTRATION DES DURCH DIE NIEREN AUSGESCHIEDENEN INH. Beitr Klin Tuberk Spezif Tuberkuloseforsch. 1964 May 27;128:213–217. [PubMed] [Google Scholar]
  12. MITCHELL R. S., BELL J. C. Clinical implications of isoniazid blood levels in pulmonary tuberculosis. N Engl J Med. 1957 Nov 28;257(22):1066–1070. doi: 10.1056/NEJM195711282572202. [DOI] [PubMed] [Google Scholar]
  13. Mydlak G., Volkmann W. Die Bedeutung der INH-Stoffwechselanalyse für die Therapie. II. Z Tuberk Erkr Thoraxorg. 1965 Nov;124(1):44–48. [PubMed] [Google Scholar]
  14. Peters J. H., Miller K. S., Brown P. Studies on the metabolic basis for the genetically determined capacities for isoniazid inactivation in man. J Pharmacol Exp Ther. 1965 Nov;150(2):298–304. [PubMed] [Google Scholar]
  15. Russell D. W. Simple method for determining isoniazid acetylator phenotype. Br Med J. 1970 Aug 8;3(5718):324–325. doi: 10.1136/bmj.3.5718.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. SUNAHARA S., URANOM, OGAWAM Genetical and geographic studies on isoniazid inactivation. Science. 1961 Nov 10;134(3489):1530–1531. doi: 10.1126/science.134.3489.1530. [DOI] [PubMed] [Google Scholar]
  17. Scott E. M., Wright R. C., Weaver D. D. The discrimination of phenotypes for rate of disappearance of isonicotinoyl hydrazide from serum. J Clin Invest. 1969 Jul;48(7):1173–1176. doi: 10.1172/JCI106081. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. TEICHMANN W., KOEHLER R. BEITRAG ZUR SCHNELLEN DIFFERENZIERUNG DES INDIVIDUELLEN INH-STOFFWECHSELS. Prax Pneumol. 1964 Aug;18:535–541. [PubMed] [Google Scholar]
  19. Tiitinen H. Isoniazid inactivation status and the development of chronic tuberculosis. Scand J Respir Dis. 1969;50(3):227–234. [PubMed] [Google Scholar]
  20. Tiitinen H., Mattila M. J., Eriksson A. W. Comparison of the isoniazid inactivation in Finns and Lapps. Ann Med Intern Fenn. 1968;57(4):161–166. [PubMed] [Google Scholar]
  21. Venkataraman P., Eidus L., Tripathy S. P. Method for the estimation of acetylisoniazid in urine. Tubercle. 1968 Jun;49(2):210–216. doi: 10.1016/0041-3879(68)90023-8. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES