Abstract
Administration of ultrasonically nebulized mist to 17 patients with obstructive lung disease resulted in a temporary deterioration of mechanical lung function with decreases in vital capacity (VC), forced expired volume in one second expressed as a percentage of VC (FEV1%), and compliance and with increased inspiratory and expiratory airway resistance. Despite hyperventilation there was an associated decrease in arterial oxygen tension. Although concomitant administration of a bronchodilator afforded protection against the bronchospastic reaction, blood gas derangements were still provoked.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abernethy J. D. Effects of inhalation of an artificial fog. Thorax. 1968 Jul;23(4):421–426. doi: 10.1136/thx.23.4.421. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cheney F. W., Jr, Butler J. The effects of ultrasonically-produced aerosols on airway resistance in man. Anesthesiology. 1968 Nov-Dec;29(6):1099–1106. doi: 10.1097/00000542-196811000-00004. [DOI] [PubMed] [Google Scholar]
- Josenhans W. T., Melville G. N., Ulmer W. T. Effects of humidity in inspired air on airway resistance and functional residual capacity in patients with respiratory diseases. Respiration. 1969;26(6):435–442. doi: 10.1159/000192624. [DOI] [PubMed] [Google Scholar]
- Marks M. B. Ultrasonic nebulization in the treatment of intractable bronchial asthma in children. J Asthma Res. 1968 Jun;5(4):253–265. doi: 10.3109/02770906809100343. [DOI] [PubMed] [Google Scholar]
- Matthews L. W., Doershuk C. F., Spector S. Mist tent therapy of the obstructive pulmonary lesion of cystic fibrosis. Pediatrics. 1967 Feb;39(2):176–185. [PubMed] [Google Scholar]
- McILROY M. B., MARSHALL R., CHRISTIE R. V. The work of breathing in normal subjects. Clin Sci. 1954 Feb;13(1):127–136. [PubMed] [Google Scholar]
- Modell J. H., Giammona S. T., Davis J. H. Effect of chronic exposure to ultrasonic aerosols on the lung. Anesthesiology. 1967 Jul-Aug;28(4):680–688. doi: 10.1097/00000542-196707000-00013. [DOI] [PubMed] [Google Scholar]
- Pflug A. E., Cheney F. W., Jr, Butler J. The effects of an ultrasonic aerosol on pulmonary mechanics and arterial blood gases in patients with chronic bronchitis. Am Rev Respir Dis. 1970 May;101(5):710–714. doi: 10.1164/arrd.1970.101.5.710. [DOI] [PubMed] [Google Scholar]
- Stevens H. R., Albregt H. B. Assessment of ultrasonic nebulization. Anesthesiology. 1966 Sep-Oct;27(5):648–653. doi: 10.1097/00000542-196609000-00016. [DOI] [PubMed] [Google Scholar]
- Tai E., Read J. Response of blood gas tensions to aminophylline and isoprenaline in patients with asthma. Thorax. 1967 Nov;22(6):543–549. doi: 10.1136/thx.22.6.543. [DOI] [PMC free article] [PubMed] [Google Scholar]