Abstract
During the past 12 years 17 patients with Cushing's disease (bilateral adrenal hyperplasia secondary to excessive pituitary adrenocorticotrophic hormone) have been treated initially with external pituitary irradiation. Of the 15 patients who have had adequate follow-up, nine showed complete biochemical remission, and one showed biochemical improvement. There were no complications. It is therefore recommended that the first mode of therapy for all patients with Cushing's disease should be pituitary irradiation if the patient's clinical condition permits.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ennuyer A., Bataïni P., Dhermain P., Throuvalas N. Place de la radiothérapie transcutanée dans le traitement des adénomes hypophysaires. Bull Cancer. 1969 Apr-Jun;56(2):135–168. [PubMed] [Google Scholar]
- Heuschele R., Lampe I. Pituitary irradiation for Cushing's syndrome. Radiol Clin Biol. 1967;36(1):27–31. [PubMed] [Google Scholar]
- LIDDLE G. W., ESTEP H. L., KENDALL J. W., Jr, WILLIAMS W. C., Jr, TOWNES A. W. Clinical application of a new test of pituitary reserve. J Clin Endocrinol Metab. 1959 Aug;19:875–894. doi: 10.1210/jcem-19-8-875. [DOI] [PubMed] [Google Scholar]
- LIDDLE G. W. Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab. 1960 Dec;20:1539–1560. doi: 10.1210/jcem-20-12-1539. [DOI] [PubMed] [Google Scholar]
- MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Orth D. N., Liddle G. W. Results of treatment in 108 patients with Cushing's syndrome. N Engl J Med. 1971 Jul 29;285(5):243–247. doi: 10.1056/NEJM197107292850501. [DOI] [PubMed] [Google Scholar]
- SILBER R. H., PORTER C. C. The determination of 17,21-dihydroxy-20-ketosteroids in urine and plasma. J Biol Chem. 1954 Oct;210(2):923–932. [PubMed] [Google Scholar]
