Skip to main content
NCBI home page
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1972 Sep 23;107(6):516–519.

Long-term follow-up studies after homograft replacement of the mitral valve

Anthony F Graham, John S Schroeder, Pat O Daily, Donald C Harrison
PMCID: PMC1940929  PMID: 5057008

Abstract

Follow-up studies on 132 patients who have received fresh aortic homograft replacement of the mitral valve since May 1967 indicate good long-term function of the valve. Clinically the majority of patients are greatly improved and are free from the risks of long-term anticoagulant therapy. Hemodynamic studies performed on 13 patients at 25 to 41 months postoperatively showed a significant decrease in left atrial and pulmonary artery pressures with a small increase in cardiac output. Late deterioration of the homograft produced severe insufficiency in four cases and organic stenosis in two cases. Reasons for isolated deterioration are suggested.

Full text

PDF
516

Images in this article

518FIG. 1
on p.518
518FIG. 2
on p.518

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARRATT-BOYES B. G. HOMOGRAFT AORTIC VALVE REPLACEMENT IN AORTIC INCOMPETENCE AND STENOSIS. Thorax. 1964 Mar;19:131–150. doi: 10.1136/thx.19.2.131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BIGELOW W. G., YAO J. K., ALDRIDGE H. E., HEIMBECKER R. O., MURRAY G. D. CLINICAL HOMOGRAFT VALVE TRANSPLANTATION. J Thorac Cardiovasc Surg. 1964 Sep;48:333–345. [PubMed] [Google Scholar]
  3. Dunlap R. W., Frye R. L., Ellis F. H., Jr Mitral valve replacement with stented aortic homograft. A hemodynamic evaluation. Arch Surg. 1969 Dec;99(6):821–824. doi: 10.1001/archsurg.1969.01340180145027. [DOI] [PubMed] [Google Scholar]
  4. Gianelly R. E., Angell W. W., Stinson E., Shumway N. E., Harrison D. C. Homograft replacement of the mitral valve. Circulation. 1968 Oct;38(4):664–671. doi: 10.1161/01.cir.38.4.664. [DOI] [PubMed] [Google Scholar]
  5. Gianelly R. E., Popp R. L., Hultgren H. N. Heart sounds in patients with homograft replacement of the mitral valve. Circulation. 1970 Aug;42(2):309–321. doi: 10.1161/01.cir.42.2.309. [DOI] [PubMed] [Google Scholar]
  6. Graham A. F., Schroeder J. S., Daily P. O., Harrison D. C. Clinical and hemodynamic studies in patients with homograft mitral valve replacement. Circulation. 1971 Sep;44(3):334–342. doi: 10.1161/01.cir.44.3.334. [DOI] [PubMed] [Google Scholar]
  7. HEIMBECKER R. O., BAIRD R. J., LAJOS T. Z., VARGA A. T., GREENWOOD W. F. Homograft replacement of the human mitral valve. A preliminary report. Can Med Assoc J. 1962 May 5;86:805–809. [PMC free article] [PubMed] [Google Scholar]
  8. Heller S. J., Carleton R. A. Abnormal left ventricular contraction in patients with mitral stenosis. Circulation. 1970 Dec;42(6):1099–1110. doi: 10.1161/01.cir.42.6.1099. [DOI] [PubMed] [Google Scholar]
  9. KERWIN A. J., LENKEI S. C., WILSON D. R. Aortic-valve homograft in the treatment of aortic insufficiency. Report of nine cases, with one followed for six years. N Engl J Med. 1962 Apr 26;266:852–857. doi: 10.1056/NEJM196204262661702. [DOI] [PubMed] [Google Scholar]
  10. LAM C. R., ARAM H. H., MUNNELL E. R. An experimental study of aortic valve homografts. Surg Gynecol Obstet. 1952 Feb;94(2):129–135. [PubMed] [Google Scholar]
  11. LOWER R. R., STOFER R. C., SHUMWAY N. E. Total excision of the mitral valve and replacement with the autologous pulmonic valve. J Thorac Cardiovasc Surg. 1961 Nov;42:696–702. [PubMed] [Google Scholar]
  12. MURRAY G. Homologous aortic-valve-segment transplants as surgical treatment for aortic and mitral insufficiency. Angiology. 1956 Oct;7(5):466–471. doi: 10.1177/000331975600700509. [DOI] [PubMed] [Google Scholar]
  13. Suzuki A., Mackrell J., Kay E. B. Mitral valve replacement with transplant valves. J Thorac Cardiovasc Surg. 1970 Jul;60(1):13–25. [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES