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. 1973 Feb 17;108(4):434–439.

An outbreak of adenovirus type 7 infection in children in Montreal

Rosalind S Brown, M Bernadette Nogrady, Leslie Spence, F W Wiglesworth
PMCID: PMC1941198  PMID: 4347082

Abstract

Thirteen infants and children with adenovirus type 7 infection proved by virus isolation are described. High fever, cough and dyspnea were the most frequent findings; in infants under 1 year of age wheezing was common. Four patients required artificial ventilation. Lobar collapse, consolidation and hyperinflation were frequent radiologic findings. None of the symptoms responded to antibiotic therapy or bronchodilator drugs. Three patients died (mortality rate of 23%). Pathologic findings were compatible with adenovirus type 7 pneumonia, and were characterized by a necrotizing bronchitis and bronchiolitis, patchy alveolar fibrinopurulent exudate and hyaline membrane formation. Some intra-alveolar epithelial cells showed strikingly abnormal nuclei and rare typical halo-outlined intranuclear inclusions were seen. Only one of eight survivors had evidence of significant chronic chest disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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